Results 61 to 70 of about 2,685 (236)

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

THE ROLE OF KNOWLEDGE MANAGEMENT PRACTICE IN ENCOURAGING ACCOUNTING FOR EMPLOYEE PRODUCTIVITY

Фінансово-кредитна діяльність: проблеми теорії та практики
Our current study aims to investigate knowledge management practices within the Indonesian culinary industry, analyze the impact of these practices on the productivity of accounting staff, and identify viable strategies for enhancing knowledge ...
Yana Ulfah, Muhammad Ikbal, Anisa Kusumawardani, Set Asmapane, Dio Caisar Darma   +4 more
doaj   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

'n Evaluering van personeelbestuurseffektiwiteit in agt boerdery-ondememingstipes in die RSA landbou

South African Journal of Business Management, 1994
The aim with this study was firstly to determine the degree of discrepancy between the work experiences and work preferences of staff, on the one hand, and the prediction of the farmer in this regard on the other; and secondly, to analyse farmers ...
L. K. Oosthuizen
doaj   +1 more source

Edukasi dan Simulasi Bekerja Sehat Selamat pada Pekerja Industri Batu Bata di Korong Tanjung Pisang Nagari Sintuk Kabupaten Padang Pariaman

Warta Pengabdian Andalas, 2021
In order to achieve success and high work productivity, informal sector businesses, which are growing fast in society, need excellent occupational health support.
Fitriyani, Mega Utami Basra, Anggela Pradiva Putri, Fauziah Hermawati   +3 more
doaj   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

DIGITALIZATION AS A FACTOR OF DEVELOPMENT OF ENTERPRISE PERSONNEL

Aktualʹnì Problemi Rozvitku Ekonomìki Regìonu, 2019
The article deals with the relevance, prerequisites and directions of training and development of personnel in terms of digitalization in domestic practice.
A. Polyanska, I. Kinash, S. Savchuk
doaj   +1 more source

Correcting Apparent Priming Bias Unveils Fertilizer Nitrogen‐Risk Archetypes of Surplus and Depletion Across Asian Rice Systems

Advanced Science, EarlyView.
Correcting the apparent priming effect resolves systematic biases in Asian rice fertilizer nitrogen accounting. Net soil retention drops below 7%, while 48% of fertilizer escapes, inflicting US$98.53 billion in annual reactive‐nitrogen damages. High‐resolution mapping uncovers N‐risk archetypes across 42% of the rice area, delivering a spatially ...
Xiuyun Liu, Siyuan Cai, Longlong Xia, Jagdish K. Ladha, Xiaoyuan Yan, Xu Zhao   +5 more
wiley   +1 more source

The Complementary Role of Exports and R&D Investments as Sources of Productivity Growth [PDF]

This paper examines two potential channels of knowledge acquisition that underlie firm productivity growth in the Taiwanese electronics industry: participation in the export market and investments in R&D and/or worker training.
Tor Winston, Mark J. Roberts, Bee Yan Aw
core  

Research Insights: How Does Firm-Embedded Productivity Affect Cross-Country Income Differences? [PDF]

The gap in productivity among countries is a fundamental factor contributing to income disparities across countries. Firm-embedded productivity, encompassing knowledge, expertise, patents, brands, and business models, contributes to approximately one ...
Inter-American Development Bank
core   +1 more source