Results 141 to 150 of about 139,892 (279)

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

Survival and Tumour Microenvironment in Spatially Distinct Regions in Patients Resected for Hepatocellular Carcinoma: A Multicentre Study. [PDF]

J Gastrointest Cancer
Nordkild SB, Klubien J, Akdag D, O'Rourke C, Georgsen JB, Nielsen PS, Steiniche T, Villadsen GE, Knudsen AR, Willemoe GL, Andersen JB, Nielsen SD, Pommergaard HL.   +12 more
europepmc   +1 more source

Dehydration‐driven organization of metabolites into NaDES‐like assemblies in orthodox seeds

New Phytologist, EarlyView.
Summary Desiccation tolerance in plants, especially during orthodox seed dehydration, relies on compatible solute accumulation, complex molecular mechanisms, and intermolecular organizations that remain poorly understood. We combined metabolite profiling, mass spectrometry imaging, and electrospray and cold‐spray ionization mass spectrometry to ...
Youcef Haddad, Thomas Delhaye, Emmanuelle Limanton, Denis Morineau, Maëna Le Corvec, Christine Deponge, Anne Levrel, Alain Moréac, Virginie Nazabal, David Rondeau, Ludovic Paquin, Alain Bouchereau   +11 more
wiley   +1 more source

Antimicrobial resistance genes and antibiotic use in chronic lung disease: a bronchoscopy study of the lower airways microbiome. [PDF]

BMJ Open Respir Res
Kringeland GD, Tangedal S, Julian D, Paytuví-Gallart A, Sanseverino W, Bertelsen RJ, Husebø GR, Knudsen KS, Lehmann S, Nielsen R, Eagan TML.   +10 more
europepmc   +1 more source

Complex Regulation of RETINOBLASTOMA‐RELATED's Interactions With E2Fs via Phosphorylation

Plant, Cell &Environment, EarlyView.
ABSTRACT Arabidopsis RETINOBLASTOMA‐RELATED (RBR) regulates cell proliferation by interacting with E2F transcription factors and DIMERISATION PARTNER, RB‐LIKE, E2F AND MULTI‐VULVAL CLASS B COMPLEX (DREAM) components. Although CDK‐CYCD phosphorylation is believed to affect RBR's E2F‐binding capacity, the precise phosphorylation events inhibiting RBR's ...
Aladár Pettkó‐Szandtner, Fruzsina Vadai‐Nagy, Magdolna Gombos, Attila Hlacs, Eszter Molnár, Annamária Marton, Csaba Vizler, Rasik Shiekh Bin Hamid, Péter Kaló, Attila Fehér, Zoltán Magyar   +10 more
wiley   +1 more source

Monolithic integration of Knudsen pumps to form a complete, self-sufficient fluidic system for microscale gas chromatography. [PDF]

Microsyst Nanoeng
Zhao X, Byambadorj T, Qian T, Xu Q, Winship D, Ma Y, Qin Y, Gianchandani YB.   +7 more
europepmc   +1 more source

Resilience of floral scent emission after florivory

Plant Biology, EarlyView.
Florivory is thought to affect floral traits, impacting pollination. However, our data suggest a stability in post‐florivory scent emission, which may guarantee the maintenance of pollinator visitation regardless of florivory, indicating a resilience of natural systems with multiple and simultaneous interactions. Created in BioRender. Tunes, P.
P. Tunes, Y. Canaveze, S. R. Machado, S. Dötterl, E. Guimarães   +4 more
wiley   +1 more source

TP53 mutation is associated with improved disease control in patients with advanced RAS wild-type colorectal adenocarcinoma treated with cetuximab and pembrolizumab. [PDF]

Int J Cancer
Fountzilas C, Rosario S, Witkiewicz AK, Withers HG, Bajor DL, Mukherjee S, Saltzman J, Maguire O, Minderman H, Chatley S, Tarquini ML, Whitworth A, Jurcevic J, Hsiao HH, Knudsen ES, Muhitch JB, Abrams SI, Kalinski P, Segal BH, Bakin A, Yuan G, Wang C, Attwood K, Iyer R, Boland PM.   +24 more
europepmc   +1 more source

The Goldilocks Effect: How the “Just Right” Writing Styles of Global Corporate Responsibility Frameworks Shapes Their Use by Businesses

Regulation &Governance, EarlyView.
ABSTRACT The 21st century has witnessed a surge in the number of global corporate responsibility (GCR) frameworks issued by international organizations (IOs). Our study investigates whether and to what extent these frameworks shape businesses' Corporate Social Responsibility (CSR) communications.
Adam William Chalmers, Robyn Klingler‐Vidra   +1 more
wiley   +1 more source

Differences in tumor mutational burden assessment: a national ring trial. [PDF]

Acta Oncol
Federspiel Secher C, Westmose Yde C, Elmedal Laursen B, Høgdall E, Sylvain Thomsen H, Svenstrup Poulsen T, Sønderkær M, Kringelbach T, Malik Aagaard Jørgensen M, Frydendahl Sick Olsen R, Elaine Sørensen A, Baudet C, Gíslason MH, Knudsen M, Buhl IK.   +14 more
europepmc   +1 more source