Results 51 to 60 of about 27,445 (253)
Advanced Science, EarlyView.Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera +10 more
wiley +1 more source
Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome
Advanced Science, EarlyView.Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel +19 more
wiley +1 more source
Advanced Science, EarlyView.This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao +13 more
wiley +1 more source
Theses and Capstone Projects Plagiarism Checker using Kolmogorov Complexity Algorithm
Walailak Journal of Science and Technology, 2019 In education, students attempt to copy previous works and are relying on prepared solutions available on the Internet in order to meet their requirements.
Marco Jr. Nañadiego Del Rosario +1 more
doaj +1 more source
Cost-effectiveness of algorithms [PDF]
Discrete Mathematics & Theoretical Computer Science, 2015 Discrete ...
Graham Farr
doaj +1 more source
Combinatorics and Kolmogorov complexity [PDF]
[1991] Proceedings of the Sixth Annual Structure in Complexity Theory Conference, 2002 The authors investigate combinatorial properties of finite sequences with high Kolmogorov complexity. They also demonstrate the utility of a Kolmogorov complexity method in combinatorial theory by several examples (such as the coin-weighing problem). >
M. Li, P.M.B. Vitanyi
openaire +1 more source
MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts
Advanced Science, EarlyView.We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang +5 more
wiley +1 more source
Advanced Science, EarlyView.Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan +11 more
wiley +1 more source
An Additively Optimal Interpreter for Approximating Kolmogorov Prefix Complexity
EntropyWe study practical approximations of Kolmogorov prefix complexity (K) using IMP2, a high-level programming language. Our focus is on investigating the optimality of the interpreter for this language as the reference machine for the Coding Theorem Method (
Zoe Leyva-Acosta +2 more
doaj +1 more source
Advanced Science, EarlyView.This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong +13 more
wiley +1 more source