Results 51 to 60 of about 1,622,352 (271)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Randomness representation in turbulent flows with Kolmogorov complexity (In laminar-turbulent transition due to periodic injection in an inlet boundary layer in a circular pipe)

open access: yesNihon Kikai Gakkai ronbunshu, 2015
The complexity or randomness of the laminar-turbulent transition process of an inlet boundary layer in a circular pipe was analyzed by use of Kolmogorov complexity which is a very important measure of the randomness of various events. In the inlet region
Masashi ICHIMIYA   +2 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

open access: yesAdvanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt   +8 more
wiley   +1 more source

Complexity Measures for Maxwell–Boltzmann Distribution

open access: yesComplexity, 2021
This work presents a discussion about the application of the Kolmogorov; López-Ruiz, Mancini, and Calbet (LMC); and Shiner, Davison, and Landsberg (SDL) complexity measures to a common situation in physics described by the Maxwell–Boltzmann distribution.
Nicholas Smaal   +1 more
doaj   +1 more source

Kolmogorov Complexity of Categories [PDF]

open access: yes, 2013
Kolmogorov complexity theory is used to tell what the algorithmic informational content of a string is. It is defined as the length of the shortest program that describes the string. We present a programming language that can be used to describe categories, functors, and natural transformations. With this in hand, we define the informational content of
openaire   +3 more sources

The process complexity and effective random tests [PDF]

open access: yes, 2005
We propose a variant of the Kolmogorov concept of complexity which yields a common theory of finite and infinite random sequences. The process complexity does not oscillate.
Schnorr, Claus Peter
core  

Teaching Complexity and Its Practical Implications in Leadership Development Programs

open access: yes, 2018
This article describes an advanced leadership seminar for senior managers and executives. The three module seminar describes how thoughtful leaders can learn to succeed even under conditions of extreme complexity. The first module describes complexity in
Hazy, James K
core   +1 more source

Simulation‐Based Analysis of Insert Pull‐Out in Nickel‐Polyurethane Hybrid Foams Using CT‐Derived Geometries

open access: yesAdvanced Engineering Materials, EarlyView.
CT‐based finite element simulations combined with in situ X‐ray computed tomography are used to analyze insert pull‐out in nickel‐coated polymer foams. Despite variations in material parameters, deformation consistently concentrates within a narrow annular region around the insert.
Yannik Bautz   +4 more
wiley   +1 more source

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