Results 61 to 70 of about 363,317 (191)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Kruskal-Wallis Test for Functional Data Based on Random Projections Generated from a Simulation of a Brownian Motion

TecnoLógicas
The k-sample problem for functional data has been widely studied from theoretical and applied perspectives. In literature, Gaussianity of the generating process is generally assumed, which may be impractical in some situations.
Rafael Meléndez Surmay, Ramón Giraldo Henao, Francisco Rodríguez Cortes   +2 more
doaj   +1 more source

Production of phosphatase by microorganisms isolated from discolored painted walls in a typical tropical environment: a Non-Parametric analysis

Arab Journal of Basic and Applied Sciences, 2018
The enzymatic activities occurring on painted walls in a tropical environment have become critical given the rate of aesthetic biodeterioration of such walls. Pigmented heterotrophic microorganisms isolated from discolored painted walls in Lagos, Nigeria
Olayide Folashade Obidi, Olushina Olawale Awe, Miriam Nwanna Igwo-Ezikpe, Foluke Okedayo Okekunjo   +3 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A COMPARISON BETWEEN SINGLE LINKAGE AND COMPLETE LINKAGE IN AGGLOMERATIVE HIERARCHICAL CLUSTER ANALYSIS FOR IDENTIFYING TOURISTS SEGMENTS

International Islamic University Malaysia Engineering Journal, 2012
Cluster Analysis is a multivariate method in statistics. Agglomerative Hierarchical Cluster Analysis is one of approaches in Cluster Analysis. There are two linkage methods in Agglomerative Hierarchical Cluster Analysis which are Single Linkage and ...
Noor Rashidah Rashid
doaj   +1 more source

Implemented Crime Prevention Strategies of PNP in Salug Valley, Zamboanga Del Sur, Philippines [PDF]

, 2017
– This study aimed primarily to determine the effectiveness of crime prevention strategies implemented by the Salug Valley Philippine National Police (PNP) in terms of Police Integrated Patrol System, Barangay Peacekeeping Operation, Anti-Criminality ...
Patalinghug, Mark
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Comparison of the number of visits and diagnostic lenses required to fit RGP, conventional hydrogel and silicone hydrogel contact lenses

Journal of Optometry, 2010
Purpose: To describe differences in the number of visits and in the number of diagnostic lenses (DL) necessary to fit rigid gas permeable (RGP), traditional hydrogel and silicone hydrogel contact lenses (CL) in non-pathological eyes.
Raul Martín, Elena Alonso
doaj   +1 more source

PENGARUH PEMBERIAN MINUMAN ISOTONIK TERHADAP MEMORI PADA KEADAAN DEHIDRASI [PDF]

, 2015
Background: Sport is one of popular activities throughout the world. One of the biggest problems found among athletes in sports is dehydration, which causes many bad health issues for athletes themselves.
Adyaksa, Gana, Prasetya, Ari, Purwoko, Yosef   +2 more
core