Results 61 to 70 of about 696,439 (238)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

E-Marketplace Brand Equity: A Study on Generational Cohort

Journal of Management and Entrepreneurship Research
Objective: This study examines generational differences in e-marketplace brand equity (eMBE) across Generation Y and Z, and compares the platforms Tokopedia and Shopee.
Yan Enggal Asmara, Albert Kriestian Novi Adhi Nugraha   +1 more
doaj   +1 more source

TELEPÜLÉSI EGÉSZSÉGEGYENLŐTLENSÉGEK A GAZDASÁGI FEJLETTSÉG TRIADIKUS FELBONTÁSA ALAPJÁN = HEALTH INEQUALITIES ON SETTLEMENT LEVEL BY THE TRIADIC RESOLUTION OF ECONOMIC DEVELOPMENT [PDF]

, 2017
Tanulmányom célja a magyar települési szintű egészségegyenlőtlenségek bemutatása a gazdasági fejlettség összefüggésében. Ezen vizsgálati célhoz a gazdasági fejlettség háromtényezős (triadikus) felbontásának módszerét hívtam segítségül, amellyel ...
Egri, Zoltán
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The Effectiveness of Diagnostic Assessments and GeoGebra-Assisted Learning on Learning Outcomes Reviewed from Learning Styles

Edumatica: Jurnal Pendidikan Matematika
This study aims to analyze the effectiveness of providing cognitive and non-cognitive diagnostic (learning style) assessments and recognizing students' learning styles before the learning process occurs.
Cecilia Novianti Salsinha, Fitriani Fitriani, Hendrika Bete, Eric Steven Hall   +3 more
doaj   +1 more source

Nonparametric Edge Detection in Speckled Imagery

, 2012
We address the issue of edge detection in Synthetic Aperture Radar imagery. In particular, we propose nonparametric methods for edge detection, and numerically compare them to an alternative method that has been recently proposed in the literature.
Alejandro C. Frery, Allende, Beauchemin, Bovik, Brigger, Bustos, Bustos, Conover, Cribari-Neto, Doornik, Edwin Girón, Fesharaki, Francisco Cribari-Neto, Freitas, Frery, Frery, Gambini, Gambini, Hoon Lim, Lim, Mejail, Mejail, Moschetti, Nascimento, Oliver, Pianto, Richards, Su, Vasconcellos, Venables   +29 more
core   +1 more source

Large scale statistical analysis of GEO datasets [PDF]

, 2014
The problem addressed here is that of simultaneous treatment of several gene expression datasets, possibly collected under different experimental conditions and/or platforms.
Charmpi, Konstantina, Fournié, Jean-Jacques, Rousseaux, Sophie, Ycart, Bernard   +3 more
core   +3 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance. [PDF]

, 2018
Bifidobacterium species are important commensals capable of dominating the infant gut microbiome, in part by producing acids that suppress growth of other taxa.
Ahmad, SM, Akre, Samir, Huda, M Nazmul, Liu, Jinxin, Maldonado-Gomez, Maria X, Mills, David A, Stephensen, Charles B, Taft, Diana H   +7 more
core   +1 more source

Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]

, 2008
<p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J., Harrow, C., Lees, K.R., Muir, S.W., Sattar, N., Walters, M.R., Weir, C.J.   +6 more
core   +1 more source