Results 31 to 40 of about 7,677 (250)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Analytical measurements of fission products during a severe nuclear accident

EPJ Web of Conferences, 2018
The Fukushima accident emphasized the fact that ways to monitor in real time the evolution of a nuclear reactor during a severe accident remain to be developed.
Doizi D., Reymond la Ruinaz S., Haykal I., Manceron L., Perrin A., Boudon V., Vander Auwera J., tchana F. Kwabia, Faye M.   +8 more
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Clinical Validation of Artificial Intelligence (AI)‐based Cartilage Segmentation Predicting Knee Replacement

Arthritis Care &Research, Accepted Article.
Objective For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human interaction. To clinically validate artificial intelligence (AI)‐based analysis, we studied cartilage loss from MRI prior to knee replacement.
Felix Eckstein, David J. Hunter, C. Kent Kwoh, Wolfgang Wirth   +3 more
wiley   +1 more source

High-pressure crystallography shows noble gas intervention into protein-lipid interaction and suggests a model for anaesthetic action

Communications Biology, 2022
Noble gases are known to interact with proteins and can be good anaesthetics in hyperbaric conditions. This study identifies argon and krypton binding sites on membrane proteins and proposes as a hypothesis that noble gases, by altering protein/lipid ...
Igor Melnikov, Philipp Orekhov, Maksim Rulev, Kirill Kovalev, Roman Astashkin, Dmitriy Bratanov, Yury Ryzhykau, Taras Balandin, Sergei Bukhdruker, Ivan Okhrimenko, Valentin Borshchevskiy, Gleb Bourenkov, Christoph Mueller-Dieckmann, Peter van der Linden, Philippe Carpentier, Gordon Leonard, Valentin Gordeliy, Alexander Popov   +17 more
doaj   +1 more source

Beyond Visual Scoring: Computational CT‐analysis for HRCT based quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Arthritis Care &Research, Accepted Article.
Interstitial lung disease (IRD‐ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRD). High‐resolution computed tomography (HRCT) is widely considered the gold standard for the non‐invasive assessment of ILD; however, its interpretation is constrained by substantial inter‐observer variability and ...
Alexander Pfeil, Tobias Hoffmann, Ulf Teichgräber, Diane Renz, Denise Beckmann, Gunter Wolf, Nicole Schadewaldt, Bianca Lassen‐Schmidt   +7 more
wiley   +1 more source

Ultrafast quantum control of ionization dynamics [PDF]

EPJ Web of Conferences, 2019
The unprecedented combination of transient absorption and ion mass spectroscopy with attosecond resolution is used to study and control the complex multidimensional excitation and decay cascade of an ultrafast Auger process in krypton.
Hütten Konrad, Mittermair Michael, Stock Sebastian, Beerwerth Randolf, Shirvanyan Vahe, Riemensberger Johann, Duensing Andreas, Heider Rupert, Wagner Martin S., Guggenmos Alexander, Fritzsche Stephan, Kabachnik Nikolay M., Kienberger Reinhard, Bernhardt Birgitta   +13 more
doaj   +1 more source

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among U.S. Veterans

Arthritis Care &Research, Accepted Article.
Biomedical research involving United States Veterans continues to advance healthcare beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where Veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source

Improved and automated krypton assay for low-background xenon detectors with Auto-RGMS

European Physical Journal C: Particles and Fields
Ultra-sensitive quantification of trace radioactive krypton-85 ( $$^{85}$$ 85 Kr) is essential for low-background experiments, particularly for next-generation searches of galactic dark matter and neutrino physics using xenon-based time projection ...
Matteo Guida, Ying-Ting Lin, Hardy Simgen   +2 more
doaj   +1 more source

Neuroprotective Effects of Krypton Inhalation on Photothrombotic Ischemic Stroke

Biomedicines
This is the first in vivo study to investigate the neuroprotective effects of krypton on focal cerebral ischemia. The aim of the study was to analyze the effect of 2 h of inhalation of a krypton–oxygen mixture (Kr 70%/O2 30%) on the recovery of ...
Viktoriya V. Antonova, Denis N. Silachev, Egor Y. Plotnikov, Irina B. Pevzner, Elmira I. Yakupova, Mikhail V. Pisarev, Ekaterina A. Boeva, Zoya I. Tsokolaeva, Maxim A. Lyubomudrov, Igor V. Shumov, Andrey V. Grechko, Oleg A. Grebenchikov   +11 more
doaj   +1 more source