Results 121 to 130 of about 31,573 (284)

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Real‐World Unmet Treatment Needs for Patients With Haemophilia: Results From the Global Adelphi Disease Specific Programme Database

Haemophilia, EarlyView.
ABSTRACT Introduction Prophylactic factor replacement and non‐factor therapy has improved bleed prevention and clinical outcomes for people with haemophilia (PwH). The remaining burdens faced by PwH in real‐world settings, despite availability of newer therapies, are not well documented.
Víctor Jiménez Yuste, Cléa Percier, Shwetha Prashanth, Nathan Ball, Ella Morton, Giancarlo Castaman   +5 more
wiley   +1 more source

Evaluation of artificial intelligence–based software programs applied to the radiographic and photographic identification of dental implant systems

Journal of Prosthodontics, EarlyView.
Abstract Purpose The purpose of this evaluation study was to assess the performance of ChatGPT‐5, Google Gemini (v2.5), and Microsoft Copilot in identifying five demonstration dental implant systems and four implants from real clinical cases based on clinical and radiographic images.
Sohil A. Kazim, Charles J. Goodacre
wiley   +1 more source

Mandarin Relative Clause Production by Second Language Learners: Subject–Object Asymmetry and Individual Differences

Language Learning, EarlyView.
Abstract This study investigated which type of Mandarin Chinese relative clause (RC)—subject‐extracted relative clause (SRC) or object‐extracted relative clause (ORC)—imposes greater processing demands on second language (L2) learners’ production. Sixty‐two native (L1) Mandarin speakers and 72 L1 Korean learners of Mandarin participated in a picture ...
Deran Kong, Sun‐A Kim, Jeong‐Ah Shin
wiley   +1 more source

Optimization of last-mile delivery in KSA

International Journal of Science and Technology Research Archive
The last-mile delivery of e-commerce orders is a critical challenge for logistics companies in Saudi Arabia. This study has demonstrated the importance of optimizing the last-mile delivery process for logistics companies in Taif city to enhance their competitiveness and meet the growing demand to achieve customer's satisfaction. The research found that
null Dalia Saber, null Najah Yousfi, null Sarra Selmi, null Manal Alotaibi, null Nora Alotaibi, null Roaa Alharthi, null Haneen Alwgdani, null Reem Alotaibi, null Manar Altalhi   +8 more
openaire   +2 more sources

Diurnal Variation and Impairment of Postprandial Glucose‐Insulin Responses and Lipid Rhythms in Simulated Shift Work

Nutrition Bulletin, EarlyView.
ABSTRACT Shift work is associated with insulin resistance, dyslipidaemia and metabolic syndrome, but how consecutive meals at the same clock times differentially shape postprandial metabolism in day‐ and night‐shifts remains unclear. This study used a unique simulated shift work intervention with four consecutive meals and high‐resolution sampling to ...
Ameena M. Khan Sullivan, Cheryl M. Isherwood, Hana Hassanin, Debra J. Skene, Daan R. van der Veen   +4 more
wiley   +1 more source

AIZHAN USSENALIYEVA CV 2025 KSA

Bio CV presentation.
openaire   +1 more source

Independent Multicentre Validation of the ‘Six‐Point’ Model for Malignant Transformation Risk in Oral Epithelial Dysplasia

Oral Diseases, EarlyView.
ABSTRACT Background Histological grading of oral epithelial dysplasia (OED) is used for predicting malignant transformation risk. However, grading is associated with significant subjectivity and observer variability leading to inconsistency in prognosis prediction.
Hanya Mahmood, Mike Bradburn, Nadim M. Islam, Omar Kujan, Nasir Rajpoot, Alan Roger Santos‐Silva, Pablo Agustin Vargas, Jacqueline James, Paul Nankivell, Hisham Mehanna, Syed Ali Khurram   +10 more
wiley   +1 more source

Factors affecting marriage decisions among couples with sickle cell or beta-thalassemia traits

Journal of Taibah University Medical Sciences
الملخص: أهداف البحث: تهدف هذه الدراسة إلى تقييم مدى انتشار الزواج بين الأزواج غير المتوافقين وراثيًا، والمُعرّضين لخطر إنجاب أطفال مصابين بفقر الدم المنجلي أو أنيميا البحر المتوسط في منطقة جازان بالمملكة العربية السعودية، بالإضافة إلى تقييم العوامل ...
Mohammed Badedi, MD, Abdulrahman Muidh, BSc, Mannaa Alsayed, BSc, Hussain Darraj, MD, Ali Shubaili, MD, Abdulaziz Darraj, MD, Yahya Hobani, Diploma, Musa Ahmadini, BSc, Ibrahim Hakami, MD, Nabeel Gharawi, MD, Mohammed Hakami, Diploma, Khalid Shrwani, PhD, Nhari Malhan, BSc, Asma Mokali, MD, Ahmed Abdaly, MD   +14 more
doaj   +1 more source

An Analysis of Proactive State Monitoring of Local Government Debt Issuance

Public Budgeting &Finance, EarlyView.
Abstract Debt monitoring rules are a type of fiscal rule that allows states to proactively oversee their local government borrowing. This study examines how these rules impact local borrowing costs using a mixed‐methods approach. It reviews state codes to classify debt monitoring features and creates a rigor index to measure state involvement.
Justina Jose
wiley   +1 more source