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KSHV/HHV8-mediated hematologic diseases
Blood, 2022Abstract Kaposi sarcoma (KS) herpesvirus (KSHV), also known as human herpesvirus 8, is the causal agent of KS but is also pathogenetically related to several lymphoproliferative disorders, including primary effusion lymphoma (PEL)/extracavitary (EC) PEL, KSHV-associated multicentric Castleman disease (MCD), KSHV+ diffuse large B-cell ...
Ethel Cesarman +2 more
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Immunotherapy for KSHV-associated diseases
Current Opinion in Virology, 2022Kaposi sarcoma herpesvirus (KSHV)-associated diseases (Kaposi sarcoma, multicentric Castleman disease, primary effusion lymphoma, and KSHV inflammatory cytokine syndrome) are associated with immune suppression and dysregulation and loss of KSHV-specific immunity.
Kathryn, Lurain +2 more
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Current Oncology Reports, 2005
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), has been linked to several malignancies in humans. KSHV is the etiologic agent associated with the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV is a double-stranded DNA virus that has been
Emily L, Wong, Blossom, Damania
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Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), has been linked to several malignancies in humans. KSHV is the etiologic agent associated with the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV is a double-stranded DNA virus that has been
Emily L, Wong, Blossom, Damania
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2008
Kaposi’s sarcoma-associated herpesvirus (KSHV) has been consistently implicated in the pathogenesis of Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). The hallmark of KSHV infection is to establish life-long persistency that has imposed enormous pressure on this virus to escape host immune recognition.
Chengyu Liang +4 more
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Kaposi’s sarcoma-associated herpesvirus (KSHV) has been consistently implicated in the pathogenesis of Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). The hallmark of KSHV infection is to establish life-long persistency that has imposed enormous pressure on this virus to escape host immune recognition.
Chengyu Liang +4 more
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KSHV infection of B-cell lymphoma using a modified KSHV BAC36 and coculturing system
The Journal of Microbiology, 2012Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of two B cell lymphoproliferative diseases, namely primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV infection of B cell lymphoma in vitro has been a long-standing battle in advancing human KSHV biology.
Hyosun, Cho, Hyojeung, Kang
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2007
Human infection by KSHV is associated with the development of at least three proliferative disorders: Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL) and a subset of multicentric Castleman’s disease (MCD). In keeping with the classification of KSHV as a lymphotropic (γ2) herpesvirus, two of these (PEL and MCD) are primary disorders of the B cell
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Human infection by KSHV is associated with the development of at least three proliferative disorders: Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL) and a subset of multicentric Castleman’s disease (MCD). In keeping with the classification of KSHV as a lymphotropic (γ2) herpesvirus, two of these (PEL and MCD) are primary disorders of the B cell
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Cell signaling pathways engaged by KSHV
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2006Kaposi's sarcoma herpesvirus (KSHV) is the eighth human herpesvirus discovered in 1994 from Kaposi's sarcoma lesion of an AIDS patient. The strong molecular and epidemiological links associating KSHV with Kaposi's sarcoma and certain lymphoproliferative disorders indicate that KSHV is required for the development of these malignancies. Although KSHV is
Annika, Järviluoma, Päivi M, Ojala
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Kshv/hhv8-associated lymphomas
Hematology Meeting Reports, 2009It was only after the discovery of KSHV/HHV8, that primary effusion lymphoma (PEL) could be recognized as a distinct entity, thanks to its consistent association with HHV-8 infection. As a consequence, PEL has been included in the recent WHO lymphoma classification, within the group of lymphomas occurring more specifically in HIV positive patients. PEL
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Regulation of KSHV Lytic Gene Expression
2006The life cycle of KSHV, latency versus lytic replication, is mainly determined at the transcriptional regulation level. A viral immediate-early gene product, replication and transcription activator (RTA), has been identified as the molecular switch for initiation of the lytic gene expression program from latency.
H, Deng, Y, Liang, R, Sun
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