Results 241 to 250 of about 425,317 (330)

RPS27L Enhances Myogenesis and Muscle Mass by Targeting IGF1 Through Liquid‐Liquid Phase Separation

Advanced Science, EarlyView.
Muscle‐specific RPS27L knock‐in mice exhibit increased body weight, muscle mass, and enhanced muscle regenerative capacity. RPS27L drives myogenesis by promoting myoblast proliferation, while inhibiting myogenic differentiation. Mechanistically, RPS27L targets IGF1 protein by liquid‐liquid phase separation through its N‐terminal intrinsically ...
Xiaoqin Liu, Yilong Yao, Junyu Yan, Mu Zeng, Xinhao Fan, Yijie Tang, Jiju Li, Yanwen Liu, Shanying Yan, Wei Wang, Lijuan Chen, Ruipu Chen, Yuxin Huang, Honor Calnan, Heng Wang, Graham Gardner, Yalan Yang, Zhonglin Tang   +17 more
wiley   +1 more source

Automatic segmentation of male pelvic floor soft tissue structures for anatomical simulation and morphological assessment in lower rectal cancer surgery. [PDF]

Tech Coloproctol
Aisu Y, Okada T, Itatani Y, Masuo A, Tani R, Fujimoto K, Kido A, Sawada A, Sakai Y, Obama K.   +9 more
europepmc   +1 more source

Comparison of Kyoto Scale of Psychological Development and Bayley Scales of Infant Development second edition among Japanese Infants

, 2013
Nozomi Tatsuta, Keita Suzuki, Tomoko Sugawara, Kunihiko Nakai, Toru Hosokawa, Hiroshi Satoh   +5 more
openalex   +2 more sources

T‐2 Toxin Exploits Gut‐Derived Staphylococcus Saprophyticus to Disrupt Hepatic Macrophage Homeostasis

Advanced Science, EarlyView.
T‐2 toxin promotes the proliferation of intestinal S. saprophyticus and facilitates its translocation to the liver in piglets and mice. The translocated bacteria trigger autophagy in Kupffer cells and recruit monocytes to the liver through the nucleotide‐binding oligomerization domain 2 (NOD2) signaling pathway, alongside the M1 polarization of hepatic
Yuanyuan Zhu, Liu Xu, Fangrui Guo, Jianyu Qu, Xiangyan Liu, Qiurong Xu, Jie Sheng, Jiangping Wang, Xiaohong Xie, Ruimin Ren, Chuan Zhou, Sisi Yan, Shuiping Liu, Zhihang Yuan, Rongfang Li, Jing Wu, Jine Yi, Yulong Yin, Lixin Wen, Ji Wang   +19 more
wiley   +1 more source

Vascular Reconstruction Device for Coil Embolization of Wide-Neck Type Cerebral Aneurysm: Findings from a Post-Marketing Surveillance Study in Japan. [PDF]

J Neuroendovasc Ther
Kawamura Y, Honda A, Hyodo A, Miyachi S, Matsumaru Y, Taki W, Ito Y, Kuwayama N, Imamura H, Izumi T, Sakai C, Sakai N.   +11 more
europepmc   +1 more source

Bone Marrow Mesenchymal Stem Cell Hydrogel‐Mediated Fibroblast Reprogramming Restores Intestinal Function in Adhesive Small Bowel Obstruction

Advanced Science, EarlyView.
Conceptual diagram and schematic illustration of microenvironmental changes in individuals with ASBO before and after treatment. BMSC@Gel therapy transforms the ASBO microenvironment from an inflammatory, fibrotic state with aberrant matrix deposition and barrier dysfunction to a regenerative state with reduced inflammation and improved structural ...
Lihong Zheng *, Junrong Zhang *, Zhengyuan Huang *, Zhenliang Lin, Jin Zhang, Da Zhang, Ping Hou, Xianqiang Chen   +7 more
wiley   +1 more source

Effectiveness of innovative health enhancement and cardiac rehabilitation support programme combining a personal health record app and counselling services for patients with ischaemic heart disease: a study protocol for a randomised controlled trial. [PDF]

BMJ Open
Yoshimura S, Shimamoto T, Tateyama Y, Yazawa M, Namba M, Nishioka N, Takahashi Y, Nakayama T, Iwami T.   +8 more
europepmc   +1 more source

Bimetal‐Phenolic Framework to Combat Bacterial Infections via Synergistic Biofilm Dispersal, Bacterial Killing and Immune Modulation

Advanced Science, EarlyView.
A bimetal‐phenolic framework (Que‐Fe‐CeMPF) is developed by direct self‐assembly through the coordination of Fe3+ and Ce4+ with quercetin. Que‐Fe‐CeMPF exhibits multimodal activity, including cleaving matrix eDNA within biofilm, generating hydroxyl radicals via catalytic H2O2 to kill bacteria, and alleviating inflammation by stimulating macrophage ...
Yaran Wang, Fan Wu, Lei Hua, Chang Gao, Siran Wang, Yong Liu, Yijin Ren, Linqi Shi, Henny C. van der Mei, Yuanfeng Li   +9 more
wiley   +1 more source

Kyoto Classification-Based Predictive Factors Associated with the Development of Gastric Cancer After <i>Helicobacter pylori</i> Eradication: A Prospective Multicenter Observational Study. [PDF]

Diagnostics (Basel)
Takayama S, Dohi O, Horie R, Yasuda T, Ochiai T, Iwai N, Imamoto E, Takagi T, Handa O, Konishi H, Ando T, Naito Y, Takemura T, Itoh Y.   +13 more
europepmc   +1 more source

Enhancing Anti‐Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression

Advanced Science, EarlyView.
CD19‐293‐EV can switch the CD19 endocytosis pathway from clathrin‐mediated endocytosis to aggregation‐dependent endocytosis, leading to lysosomal degradation of the CD19/EVs complex. Degradation of the EVs leads to impairment in the IFN response and enhancement in EV uptake by target cells, creating a potent feedback cycle.
Zixuan Huang, Chaoqun Lu, Yixin Wang, Huajian Xian, Yuling Zheng, Ting Kang, Rufang Xiang, Shufeng Xie, Minghui Wang, Zeyi Li, Xiaoli Xia, Yaoyifu Yu, Wenjie Zhang, Huijian Zheng, Renyao Pan, Dan Li, Chunjun Zhao, Han Liu   +17 more
wiley   +1 more source