Results 251 to 260 of about 1,880,497 (367)

Adherence to Surgical Antimicrobial Prophylaxis Guidelines and Improvement Efforts: A Single-Center, Pre- and Post-Intervention Comparison Study. [PDF]

Health Sci Rep
Yamamoto C, Nukui Y, Kosaka T, Aoto K, Kozen R, Hasegawa K, Ota C, Inoue Y, Taniguchi M, Hamashima R, Furukawa K, Kikuchi K, Nakanishi A, Teramukai S, Horii Y, Sawa T.   +15 more
europepmc   +1 more source

EXPERIMENTAL DISCUSSION ON THE EVALUATION OF BUILDING FACADE DESIGN FROM THE VIEWPOINT OF COMBINED ENVIRONMENTAL EVALUATION : Case of Japanese style, Western style, and contemporary style buildings in Kyoto city

, 2005
Hiromitsu Yokoyama, Naoki Matsubara, Akira Gassho, Yoshihito Kurazumi   +3 more
openalex   +2 more sources

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

State-transition trajectories in out-of-hospital cardiac arrest: neurological outcomes beyond myocardial activity. [PDF]

Crit Care
Kandori K, Matsuyama T, Kitamura T, Narumiya H, Ishii W, Hitosugi M, Okada Y.   +6 more
europepmc   +1 more source

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Suspected Fatal Arrhythmic Events in Japanese Patients With Coronary Artery Disease　― From the CREDO-Kyoto PCI/CABG Registries Cohorts-2 and -3 ―

Koji Hanazawa, Hiroki Shiomi, Takeshi Morimoto, Kenji Andò, Yutaka Furukawa, Tomohisa Tada, Junichi Tazaki, Kazushige Kadota, Toshihiro Tamura, Yukihito Sato, Mitsuo Matsuda, Moriaki Inoko, Manabu Shirotani, Tomoya Onodera, Eiji Shinoda, Takashi Yamamoto, Takashi Tamura, Shinji Miki, Takeshi Aoyama, Satoru Suwa, Kenji Minatoya, Yoshiharu Soga, Tadaaki Koyama, Tatsuhiko Komiya, Nobuhisa Ohno, Tatsuya Ogawa, Fumio Yamazaki, Junichiro Nishizawa, Jiro Esaki, Naoki Kanemitsu, Yoshihisa Nakagawa, Takeshi Kimura, on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort -2 and -3 Investigators   +32 more
openalex   +2 more sources

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, EarlyView.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source