Results 21 to 30 of about 197,028 (313)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Migration and Networks in Early Modern Kyoto, Japan [PDF]

International Review of Social History, 2002
The question of assimilation networks for migrants is usually applied to international migration. In this study, however, I use the population registers for a neighborhood in early modern Kyoto to look for possible network connections in domestic migration.
openaire   +2 more sources

Characteristics, risk factors and mortality of stroke patients in Kyoto, Japan [PDF]

BMJ Open, 2013
ObjectivesThe aim of the study was to evaluate the characteristics, risk factors and outcome of recent stroke patients in Kyoto, Japan.DesignWe analysed stroke patients in the registry with regard to their characteristics, risk factors and mortality. Cox proportional hazards regressions were used to calculate adjusted HRs for death.SettingsThe Kyoto ...
Akihiko Nishizawa, Yoshiyuki Watanabe, Kazuo Shigematsu, Tatsuyuki Sekimoto, Masahiro Makino, Hiromi Nakano, Kouichiro Shimizu, Atsushi Okumura, Kazuhiko Bando, Yasushi Kitagawa   +9 more
openaire   +3 more sources

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Belly roll, a GPI-anchored Ly6 protein, regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons

eLife, 2023
Appropriate modulation of escape behaviors in response to potentially damaging stimuli is essential for survival. Although nociceptive circuitry has been studied, it is poorly understood how genetic contexts affect relevant escape responses.
Kai Li, Yuma Tsukasa, Misato Kurio, Kaho Maeta, Akimitsu Tsumadori, Shumpei Baba, Risa Nishimura, Akira Murakami, Koun Onodera, Takako Morimoto, Tadashi Uemura, Tadao Usui   +11 more
doaj   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Clinical outcomes after initial treatment of methicillin-resistant Staphylococcus aureus infections

Infection and Drug Resistance, 2018
Nobuaki Shime,1,2 Nobuyuki Saito,3 Miya Bokui,4 Naoki Sakane,5 Mitsuhiro Kamimura,6 Tsutomu Shinohara,7 Tadashi Kosaka,8 Hisashi Ishikura,9 Atsuko Kobayashi,10 1Department of Emergency and Critical Care Medicine, Graduate School of Biomedical & ...
Shime N, Saito N, Bokui M, Sakane N, Kamimura M, Shinohara T, Kosaka T, Ishikura H, Kobayashi A   +8 more
doaj  

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

FEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima   +7 more
wiley   +1 more source

Whole-body and segmental muscle volume are associated with ball velocity in high school baseball pitchers

Open Access Journal of Sports Medicine, 2013
Yosuke Yamada,1,2 Daichi Yamashita,2,3 Shinji Yamamoto,2,3 Tomoyuki Matsui,4 Kazuya Seo,4 Yoshikazu Azuma,4 Yoshikazu Kida,5 Toru Morihara,5 Misaka Kimura1 1Laboratory of Sports and Health Science, Kyoto Prefectural University of Medicine, Kyoto, Japan ...
Yamada Y, Yamashita D, Yamamoto S, Matsui T, Seo K, Azuma Y, Kida Y, Morihara T, Kimura M   +8 more
doaj