Results 101 to 110 of about 1,710,062 (294)
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Advanced Science, EarlyView.We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li +9 more
wiley +1 more source
Hot air in Kyoto, cold air in The Hague [PDF]
Why did the climate negotiations in The Hague fail? Our contribution is to argue that the conflict between the European Union and the United States stems mainly from disagreement on the cost issue.
Urs Steiner Brandt +1 more
core
The competitive environment of the European electricity sector in the post-Kyoto scenarios [PDF]
This paper shows how the uncertainty associated to the absence of a post-Kyoto regime regarding Greenhouse Gas mitigation is affecting investments in mitigation activities in the EU electricity sector and, thus, future emissions levels.
García, Carlos +3 more
core +2 more sources
Advanced Science, EarlyView.A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo +18 more
wiley +1 more source
What a Difference Kyoto Made: Evidence from Instrumental Variables Estimation [PDF]
The Kyoto Protocol’s success or failure should be evaluated against the unobserved counterfactual of no treatment. This requires instrumental variables.
Gabriel Felbermayr, Rahel Aichele
core
The Kyoto protocol : Russian opportunities [PDF]
, 2004 Much, possibly too much, of the most recent debate on Russian ratification of the Kyoto Protocol has centred around the issue whether the Kyoto emission limit would hinder Russian economic growth, particularly in the context of the ambitious decadal ...
Müller, Benito
core
Transparency and Kyoto Protocol: reply to Mollicone and Federici
Forest@, 2007 A reply to the letter by Mollicone and Federici, published in the current issue of this journal, and a restatement of the transparent objectives and expected results from the CarboItaly project.
Gianelle D +11 more
doaj
Smoke and Mirrors: The Kyoto Protocol and beyond
Canadian Public Policy / Analyse de Politiques, 2003 The Kyoto Protocol is considered a necessary first step toward an effective future climate accord. As argued in this paper, however, the protocol will likely fail because it has too many loopholes, inadequate governance structures, and insufficient compliance provisions.
openaire +1 more source
Advanced Science, EarlyView.We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen +5 more
wiley +1 more source