Results 211 to 220 of about 2,241,424 (335)

Conventional Versus Underwater Endoscopic Mucosal Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors ≤ 20 mm: Study Protocol for a Multicenter Randomized Controlled Trial (D-CURE Trial). [PDF]

Methods Protoc
Yoshida M, Hatta W, Nakamura T, Nakaya N, Shichijo S, Tanaka Y, Kanzaki H, Hirasawa K, Oda I, Hirose T, Kato M, Takizawa K, Toya Y, Hikichi T, Sawai H, Yoshida N, Dohi O, Masamune A, Abe S, Yano T, D-CURE Trial Group.   +20 more
europepmc   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Recovery of functional ambulation through stepwise rehabilitation treatment in a patient with encephalomyeloradiculoneuropathy: A case report. [PDF]

SAGE Open Med Case Rep
Sawada K, Morii F, Hishikawa N, Maeda H, Iwasaki Y, Nakamura M, Shimizu Y, Kojima Y, Ohara T, Mikami Y.   +9 more
europepmc   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Messenger RNA-encoded reporters for monitoring cellular stress and bioenergetics. [PDF]

Sci Rep
Hwang KK, Fang Q, Nizard C, Bulteau AL, Woltjen K.   +4 more
europepmc   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Long-term outcomes of low-dose dasatinib in older patients with chronic myeloid leukemia in chronic phase: an extended follow-up of the DAVLEC phase 2 trial. [PDF]

Blood Cancer J
Ureshino H, Murai K, Kumagai T, Mino T, Nishiwaki K, Wakita S, Takeoka T, Mita M, Yoshida C, Uoshima N, Fukushima T, Kuroda J, Kondo T, Chiba M, Miyazaki T, Io K, Ueda T, Ono T, Usuki K, Yamauchi T, Fujimaki K, Ikezoe T, Kawaguchi A, Kimura S.   +23 more
europepmc   +1 more source

Towards a successful international greenhouse gas emissions trading

The inclusion of emissions trading in the Kyoto Protocol reflects an important decision to address climate change issues through flexible market mechanisms.
Zhang, ZhongXiang
core  

A Sprayable Nanoplatform Breaks the Vicious Cycle of Diabetic Wounds via Photoactivated Antioxidant and Drug Delivery

Advanced Science, EarlyView.
A sprayable near‐infrared‐activated nanoplatform incorporating MXene, ZnHCF nanozyme, and deferoxamine efficiently breaks the vicious cycle of diabetic wounds. Upon irradiation, interfacial electron transfer and photothermal effects enhance multi‐enzyme activity, enabling explosive ROS elimination, alleviation of hypoxia, and controlled DFO release ...
Jiahao Guo, Yuanyuan Meng, Qixiang Gui, Xi‐Tao Yang, Yong Fan, Xiaodong Zhu   +5 more
wiley   +1 more source

Health-related quality of life with pertuzumab retreatment: Secondary analysis of the PRECIOUS trial. [PDF]

Breast
Taira N, Yamamoto Y, Iwata H, Saji S, Takahashi M, Yoshinami T, Ueno T, Toyama T, Takano T, Kashiwaba M, Tsugawa K, Tada H, Hara F, Fujisawa T, Niikura N, Morita S, Masuda N.   +16 more
europepmc   +1 more source