Results 241 to 250 of about 2,241,424 (335)

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Generation of therapeutic T cells from human induced pluripotent stem cells. [PDF]

Inflamm Regen
Wang B, Kaneko S.
europepmc   +1 more source

Donor Extended Blue TADF Dendrimer for High‐Performance Solution‐Processed OLEDs

Advanced Science, EarlyView.
A dendronized MR‐TADF emitter, DOBNA‐SpAc‐DCz, was designed to improve solubility, hole transport, and exciton dynamics for solution‐processed OLEDs. Incorporation of ter(tert‐butylcarbazole) dendrons decreases ΔEST and accelerates RISC, yielding short delayed lifetimes (∼2 µs).
Mahni Fatahi, Yuka Yasuda, Ryo Kondo, Hironori Kaji, Eli Zysman‐Colman   +4 more
wiley   +1 more source

Bifidobacterium bifidum G9-1 Intake Improves Gastrointestinal Symptoms in Type 2 Diabetes Mellitus: An Open-Label, Randomized Controlled Trial (Binary STAR Study). [PDF]

Diabetes Obes Metab
Kobayashi G, Hashimoto Y, Matsuyama T, Kitagawa N, Majima S, Senmaru T, Ushigome E, Okada H, Nakanishi N, Hamaguchi M, Fukui M.   +10 more
europepmc   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Correction: Smartphone App-Based Eating Behavior Monitoring and Feedback Intervention for Glucocorticoid-Induced Appetite Increase in Patients With Systemic Lupus Erythematosus: Protocol for a Pilot Randomized Controlled Trial. [PDF]

JMIR Res Protoc
Yamaguchi T, Takahashi N, Inanaga R, So R, Kikuchi H, Noma H, Sasai H, Kamada K, Sugimoto T, Tsushima H, Ichikawa T, Miyake H, Fujita S, Ono K, Miwa Y, Hasegawa A, Suzuki N, Onishi A, Matsui T, Watanabe R, Hasegawa Y, Ono R, Isozaki T, Ishikawa Y, Yajima N, Kurita N.   +25 more
europepmc   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Association between frequency of makeup use and depressive symptoms among community-dwelling older Japanese women. [PDF]

JAR Life
Kiuchi Y, Nakakubo S, Nosaka S, Misu Y, Nishimoto K, Gomi T, Nishikori S, Abe K, Takemoto T, Shimada H.   +9 more
europepmc   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Hispidin Ameliorates Acute Ultraviolet B-Induced Skin Inflammation by Targeting Reactive Oxygen Species-Dependent Neutrophil Extracellular Trap Formation. [PDF]

Int J Mol Sci
Arakaki Y, Tominaga K, Hiramoto K, Imai M, Morita A, Tsutsumi T, Yasuda H, Sato EF.   +7 more
europepmc   +1 more source