Results 21 to 30 of about 245,162 (297)
iForest - Biogeosciences and Forestry, 2010 Given the greater vulnerability of developing countries to climate change, their paramount interest is to establish effective mitigation policies including the land use and forestry sectors as part of the post-2012 Climate Agreement.
Federici S, Galluzzi G
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
From Kyoto to Copenhagen: Meeting the Climate Change Challenge [PDF]
In spite of some superficial success in achieving its overall global target, there has been much disillusionment with the progress on climate change since the Kyoto Protocol was negotiated in 1997.
Gaisford, James D.
core +4 more sources
Restrictions of the Kyoto protocol and sustainability of biosphere
RUDN Journal of Ecology and Life Safety, 2012 The paper analyzes the interrelation of the Kyoto Protocol and possibility of a sustainable development of biosphere.
A I Kurbatova, A M Tarko
doaj
A Criticism of the Kyoto Protocol with an Objective Approach
Journal of Advanced Research in Natural and Applied SciencesThe Kyoto Protocol, established to reduce greenhouse gas emissions, one of the human-induced causes of climate change, imposes obligations on developed countries.
Sertaç Atabey, Z. Fuat Toprak
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Indonesian Journal of Computing, Engineering and Design, 2020 The energy sector has been the highest contributor of green-house gases (GHG) emission in Japan. To reduce GHG emissions, the development and applications of cleaner technologies supported by effective policies are required.
I Ihara +3 more
doaj +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source