Results 151 to 160 of about 551,623 (249)

Data‐Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain

Advanced Science, EarlyView.
Machine learning models predict in real time the onset of harmful microbubble collapse during microbubble‐enhanced focused ultrasound (MB‐FUS) and enable dynamic adjustment of sonication to prevent cavitation‐induced damage. This predictive control expands the safe operating window for bloodbrain barrier opening, enhancing nanoparticle delivery and ...
Hohyun Lee, Victor Menezes, Shiqin Zeng, Chulyong Kim, Cynthia M. Baseman, Jae Hyun Kim, Samhita Padmanabhan, Pranav Premdas, Naima Djeddar, Anton Bryksin, Nikhil Pandey, Pavlos Anastasiadis, Anthony J. Kim, Tobey J. MacDonald, Chetan Bettegowda, Graeme F. Woodworth, Felix J. Herrmann, Costas Arvanitis   +17 more
wiley   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Landscape of Phenotype-Genotype Correlations in Romanian Patients with Medullary Thyroid Carcinoma. [PDF]

Cancers (Basel)
Stanescu LS, Lider-Burciulescu SM, Muresan A, Schipor SV, Braha E, Gheorghiu ML, Badiu C.   +6 more
europepmc   +1 more source

El líder en la empresa [PDF]

, 2011
Moya Hiniesta, Fernando Segundo
core  

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Tailored multifunctional polysiloxanes as advanced emulsifiers in colloid systems. [PDF]

Sci Rep
Olejnik A, Sztorch B, Frydrych M, Krysiak-Smułek K, Leśniewska J, Przekop RE.   +5 more
europepmc   +1 more source

Electric‐Fish‐Inspired Thin Hydrogel Electrocytes Achieve High Power Density and Environmental Robustness

Advanced Science, EarlyView.
This study presents thin, environmentally stable hydrogel power sources inspired by electric fish. Made using layer‐by‐layer spin‐coating with glycerol‐enhanced solutions, they offer precise layer control, long‐term hydration, and anti‐freezing stability.
Dor Tillinger, Wonbae Lee, Haley M. Tholen, Derek M. Hall, Joseph S. Najem   +4 more
wiley   +1 more source

Innovative Multilayer Biodegradable Films of Chitosan and PCL Fibers for Food Packaging. [PDF]

Foods
Jakubska J, Hudecki A, Kluska D, Grzybek P, Gołombek K, Pakieła W, Spałek H, Włodarczyk P, Kolano-Burian A, Dudek G.   +9 more
europepmc   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Rosa Santacana. La dona del líder [PDF]

, 1998
Salat i Noguera, M. Teresa
core