Results 121 to 130 of about 182,849 (238)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
RIO GRANDE DO SUL (Brasil). Mapas generales. 1:716846 (17) [PDF]
Título tomado de anotación en el mapaGraduado, 1 grado de latitud [= 15,5 cm]Relieve representado por normalesSeñala el itinerario seguido en los reconocimientosPertenece a los mapas levantados por la Comisión de Límites del Sur del BrasilCopia digital ...
Comisión de Límites del Sur del Brasil
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Ciclos límites en minirobots neurocontrolados [PDF]
, 1999 Este artículo presenta el análisis de estabilidad de un pequeño robot controlado con una red neuronal multicapa; por simplicidad, el robot contiene un sensor de posición y un motor. La función descriptiva de la red neuronal se utiliza para determinar los
Jesús Alberto Delgado +2 more
core
Notas acerca de los límites a la pretensión de cumplimiento del contrato
Revista de Derecho (Coquimbo), 2015 La ejecución forzada o, como preferiremos llamarle, la pretensión específica en favor del acreedor ante el incumplimiento, debe quedar sometida a ciertos límites si se le considera entre otros remedios a la inejecución del contrato.
Carlos Pizarro Wilson
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Límites del mercado, límites del Estado. Ensayos sobre la economía política del Estado
, 1995 Reseña del libro de José Luis Ayala Espino, Límites del mercado, límites del Estado.
Corona Armenta, Gabriel
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source