Results 111 to 120 of about 66,148 (263)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

ĐÁNH GIÁ MỨC ĐỘ HÀI LÒNG CỦA NGƯỜI NỘP THUẾ ĐỐI VỚI CHẤT LƯỢNG DỊCH VỤ TUYÊN TRUYỀN HỖ TRỢ TẠI CỤC THUẾ TỈNH KIÊN GIANG [PDF]

, 2013
Nghiên cứu này đã ứng dụng thang đo của Parasuraman để đo lường  mức độ hài lòng của người nộp thuế về chất lượng dịch vụ tuyên truyền hỗ trợ tại Cục Thuế tỉnh Kiên Giang. Trên cơ sở lý thuyết về chất lượng dịch vụ công cộng, kế thừa phương pháp đánh giá
Dang Thanh Son, Le Kim Long, VANA CUONG DO   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

CSA: Thực hành nông nghiệp thông minh với khí hậu ở Việt Nam

, 2017
During the last five years, Vietnam has been one of the countries most affected by climate change. Severe typhoons, flooding, cold spells, salinity intrusion, and drought have affected agriculture production across the country, from upland to lowland ...
Cao Anh Duong, DO, Trong Hieu, Duc Minh, Ngo, Huu Cuong, Ho, Khai Hoan, Le, Ngoc Quyen, Luu, Quang Thuong, Ha, Tan Yen, Bui, The Tuong, Tran, Thi Da, Che, Thi Hoa Sen, Le, Thi Sen, Pham, Thi Thanh Hai, Nguyen, Van Chinh, Nguyen, Van Trinh, Mai, Viet Dung, Le   +15 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effect of implant abutment surface treatments on bacterial biofilm composition and structure

Journal of Oral Microbiology
Background For the long-term success of dental implants, implant abutment surface should promote the attachment of oral epithelial cells and reduce bacterial adhesion. Titanium nitride (TiN) coatings show antimicrobial properties.
Eduardo Anitua, Alia Murias-Freijo, Roberto Tierno, Ricardo Tejero, Mohammad Hamdan Alkhraisat   +4 more
doaj   +1 more source

CÁC NHÂN TỐ ẢNH HƯỞNG ĐẾN Ý ĐỊNH TRỞ THÀNH CỐ VẤN KHỞI NGHIỆP: MỘT NGHIÊN CỨU TẠI MIỀN TRUNG VIỆT NAM [PDF]

This study explored the factors influencing the intention to become a startup mentor in Central Vietnam. The research employed a mixed-methods approach, utilizing surveys and in-depth interviews to collect data from current and potential startup mentors.
Nguyễn, Văn Huân, Toản, Hoàng Kim, Trần, Thị Thu Giang   +2 more
core   +1 more source