Results 11 to 20 of about 320 (73)
EFSA Journal, 2020 Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of l‐cysteine monohydrochloride monohydrate produced by fermentation using two non‐genetically modified strains of Escherichia coli K12 (E.
Baltasar Mayo +2 more
exaly +2 more sources
FEBS Open Bio, Volume 13, Issue 3, Page 468-477, March 2023., 2023 In this study, several cell lines expressing functional T1Rs (from medaka fish or zebrafish) with a chimeric G‐protein (G16gust44) were constructed using the Flp‐In system. Functional assays were conducted with the cell lines, and mfT1R2c/mfT1R3 and zfT1R2a/zfT1R3 were identified as highly sensitive taste receptors to l‐proline.
Ryusei Goda +2 more
wiley +1 more source
EFSA Journal, Volume 20, Issue 4, April 2022., 2022 Abstract Following a request from the European Commission, the FEEDAP Panel was asked to deliver a scientific opinion on the safety and efficacy of l‐methionine ≥ 98.5% or ≥ 90% produced by the combined activities of Corynebacterium glutamicum KCCM 80245 and Escherichia coli KCCM 80246) as nutritional additive for all animal species. The two production
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +21 more
wiley +1 more source
EFSA Journal, Volume 19, Issue 7, July 2021., 2021 Abstract The qualified presumption of safety (QPS) approach was developed to provide a regularly updated generic pre‐evaluation of the safety of biological agents, intended for addition to food or feed, to support the work of EFSA's Scientific Panels.
EFSA Panel on Biological Hazards (BIOHAZ) +27 more
wiley +1 more source
EFSA Journal, Volume 19, Issue 1, January 2021., 2021 Abstract The qualified presumption of safety (QPS) approach was developed to provide a regularly updated generic pre‐evaluation of the safety of biological agents, intended for addition to food or feed, to support the work of EFSA's Scientific Panels. It is based on an assessment of published data for each agent, with respect to its taxonomic identity,
EFSA Panel on Biological Hazards (BIOHAZ) +27 more
wiley +1 more source
Clinical and Translational Science, Volume 13, Issue 6, Page 1217-1226, November 2020., 2020 This open‐label, multicenter, phase I therapeutic protein‐drug interaction study was designed to evaluate the potential effect of guselkumab, a fully human anti‐interleukin‐23 immunoglobulin G1 lambda monoclonal antibody, on the pharmacokinetics of a cocktail of representative cytochrome P450 (CYP) probe substrates (midazolam (CYP3A4), S‐warfarin ...
Yaowei Zhu +8 more
wiley +1 more source
EFSA Journal, Volume 18, Issue 7, July 2020., 2020 Abstract The qualified presumption of safety (QPS) was developed to provide a generic safety evaluation for biological agents to support EFSA's Scientific Panels. It is based on an assessment of the taxonomic identity, the body of knowledge, safety concerns and antimicrobial resistance.
EFSA Panel on Biological Hazards (BIOHAZ) +26 more
wiley +1 more source
EFSA Journal, Volume 18, Issue 2, February 2020., 2020 Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of l‐cysteine monohydrochloride monohydrate produced by fermentation using two genetically modified strains of Escherichia coli K12 (Escherichia ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +30 more
wiley +1 more source
Shikimate pathway disruption in yeast induces metabolite self‐assembly into toxic aggregates
The FEBS Journal, Volume 293, Issue 14, Page 4254-4267, July 2026.In Saccharomyces cerevisiae, shikimate pathway disruption induces toxic metabolite assemblies. Deleting ARO4 plus phenylalanine (Phe) feeding causes Phenylalanine accumulation, lowers ARO3 activity, and triggers amyloid‐like fibril formation. Deleting ARO3 plus tyrosine (Tyr) feeding leads to Tyrosine buildup and similar fibril assembly.
Hanaa Adsi +6 more
wiley +1 more source
EFSA Journal, Volume 24, Issue 1, January 2026.Abstract The qualified presumption of safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of relevant knowledge and safety of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ) +28 more
wiley +1 more source