Results 131 to 140 of about 983,702 (265)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Quiet Periods in Edge Turbulence Preceding the L-H Transition in NSTX
, 2010 This paper describes the first observations in NSTX of ‘quiet periods’ in the edge turbulence preceding the L-H transition, as diagnosed by the GPI diagnostic near the outer midplane separatrix.
Roquemore, A. L. +7 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Impact of Rotational-Transform Profile Control on Plasma Confinement and Stability in CHS
, 1994 "In neutral beam heated plasma of CHS, which is a low aspect-ratio heliotron/torsatron device, the effect of rotational transform (chi) profile shape on plasma confinement and stability is studied by inducing a net plasma current (Ip).
Kawahata, K. +34 more
core
L-H transition in the mega-Amp spherical tokamak
, 2002 H-mode plasmas have been achieved on the MAST spherical tokamak at input power considerably higher than predicted by conventional threshold scalings.
Dnestrovskij, Y. N. +40 more
core +1 more source
Effect of Artificial Aging Conditions on Mechanical Properties of EN AW 6056 Aluminum Alloy
MetalsThe 6xxx series aluminum alloys are preferred in many industrial applications because they can achieve relatively high strength levels through heat treatment.
Gizem Ay +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Evidence of Zonal-Flow-Driven Limit-Cycle Oscillations during L-H Transition and at H-mode Pedestal of a New Small-ELM Regime in EAST [PDF]
, 2012 Small-amplitude edge localized oscillations have been observed, for the first time, in EAST preceding the L-H transition at marginal input power, which manifest themselves as dithering in the divertor D signals at a frequency under 4 kHz, much lower than
Wan, B. +8 more
core