Results 181 to 190 of about 24,679,940 (258)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Reversible layered/non-layered phase transition in a topological semimetal. [PDF]

Nat Commun
Liang Q, Chen J, Xie Z, Shi X, Yang L, Jiang W, Zhou J, Zheng S.   +7 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Thermodynamics of Concomitant Charge-Transfer, Antiferromagnetic, and Isostructural Phase Transitions in Barocaloric ACu₃Fe₄O₁₂ Quadruple Perovskites. [PDF]

Adv Sci (Weinh)
Delgado-Quesada J, Guzmán-Verri GG.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Rapid Change of Hydrogen Neutral Energy Distribution at L/H-Transition in JFT-2M H-mode

"Rapid changes of the main ion energy distribution at transitions from L-to-H, H-to-L and during ELMs are studied with the time of flight neutral measurement on the JFT-2M tokamak.
JFT-2M, Group, "Miura, Y., Hoshino, K., Maeda, H., Itoh, K.", Itoh, S.-I., Takizuka, T., Okano, F., Mori, M., Suzuki, N.   +9 more
core  

Experimental Insight into Thermally Driven Structural Evolution and Metastable Dynamics of Cholesteric Liquid Crystal Droplets. [PDF]

Molecules
Xie S, Zhang H, Jiang L, Zhang H, Li P, Zhang A, Li C, Xiao Z.   +7 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The pressure effect on the crystal structure and vibration spectra of the brownmillerite Ca₂FeCoO₅ compound. [PDF]

RSC Adv
Khiem LH, Kichanov SE, Lis ON, Lukin EV, Nguyen NT, Golosova NO, Asadov AG, Hoang TP, Nguyen TT, Tien NV, Thao LTP, Dang NT.   +11 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source