Results 191 to 200 of about 761,552 (218)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Behavioral impact of condensed repeated ethanol dosing on withdrawal in adult zebrafish (<i>Danio rerio</i>). [PDF]

Front Syst Neurosci
Prince R, Steman T, Hagen EV, Johnson AL, Zhang Y, Hamilton TJ.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

6.1% Volumetric Negative Thermal Expansion Induced by the Reversible Reconstructive Phase Transition in Pb-Free Bi_1- _xLn_xCoO₃ (Ln: Lanthanoid). [PDF]

Adv Sci (Weinh)
Sakai Y, Takahashi K, Wakazaki S, Nishikubo T, Miyake J, Koike T, Nagase T, Yamamoto T, Hatayama K, Mizumaki M, Azuma M.   +10 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte-Mediated Fibrosis and Protecting Nucleus Pulposus Cells. [PDF]

Adv Sci (Weinh)
Ma F, Zhao Z, Guo C, Liu Y, Wang Y, Yao D, Lan W, Zhong D, Fan C, He Y, Zhang M, Kong Q, Lin Y.   +12 more
europepmc   +1 more source

Recent advances in metal-free functionalization of 1,4-benzoxazin-2-one scaffolds. [PDF]

RSC Adv
Thakur RK, Keshav K, Patel OPS, Vyas G, Jha AK, Ravi R, Kumar S, Tyagi MK.   +7 more
europepmc   +1 more source

Identification of Flavonoids in the Xylem of <i>Castanopsis hystrix</i> and Their Content Variation Patterns During Heartwood Formation. [PDF]

Metabolites
Ma R, Wei L, Zhu P, Liu H, Liu B, Qi J.
europepmc   +1 more source

Changes in fatty acid profiles of transition milk of Czech Fleckvieh cows milked in automatic milking system. [PDF]

Vet Anim Sci
Farková V, Dadáková K, Farka Z, Mascrez S, Eggermont D, Purcaro G, Kašparovský T, Křížová L.   +7 more
europepmc   +1 more source