Results 181 to 190 of about 24,472,241 (258)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Mallory-Weiss tear with intestinal obstruction: case report and literature review. [PDF]

J Surg Case Rep
Gharib DT, Ghalib OH, Salih SH, Tahir SH, Najar KA, Asaad HR, Hamahussein KF, Yousif RA, Abdalla BA, Kakamad FH.   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Rapid Change of Hydrogen Neutral Energy Distribution at L/H-Transition in JFT-2M H-mode

"Rapid changes of the main ion energy distribution at transitions from L-to-H, H-to-L and during ELMs are studied with the time of flight neutral measurement on the JFT-2M tokamak.
JFT-2M, Group, "Miura, Y., Hoshino, K., Maeda, H., Itoh, K.", Itoh, S.-I., Takizuka, T., Okano, F., Mori, M., Suzuki, N.   +9 more
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Tuning the optical and magnetic properties of Tb³⁺-doped ZnO quantum dots: structural investigation and Judd-Ofelt theoretical analysis. [PDF]

Nanoscale Adv
Hien NT, Thuy NTM, Van NTK, Luyen NT, Hoang LV, Yen VH, Ngoc T, Hung LX, Ca NX.   +8 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The OsSPL-SNB complex orchestrates the reproductive transition through tillering suppression in rice. [PDF]

aBIOTECH
Fan J, Chen S, Zhang J, Zhao X, Yuan Z.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Spectroscopic evidence for a first-order transition to a possible orbital Fulde-Ferrell-Larkin-Ovchinnikov state. [PDF]

Nat Commun
Cao Z, Liao M, Yan H, Zhu Y, Zhang L, Watanabe K, Taniguchi T, Morpurgo AF, Liu H, Xue QK, Zhang D.   +10 more
europepmc   +1 more source