Results 171 to 180 of about 1,327,176 (293)

Role of cystatin C in predicting the risk of hypermethotrexemia and kidney injury after high-dose methotrexate chemotherapy in childhood acute lymphoblastic leukemia. [PDF]

Ann Hematol
Pei W, Zhang X, Du LA, Liu Z, Song L, Ji M, Mou X, Ding L, Li F, Li X, Yang X.   +10 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Association Between Serum Uric Acid to Creatinine Ratio and the Severity of Acute Pancreatitis. [PDF]

Pancreas
Xu Y, Wang Y, Yu Q, Huang X, Li J, Zhang X, Chen X, Chen Y.   +7 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A machine learning predictive model based on conventional two-dimensional echocardiography and serum biomarkers for early detection of ascending aorta dilation in BAV patients. [PDF]

Front Cardiovasc Med
Long X, Niu Y, Nie G, He S, Cui L, Na L.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

2,2'-Biquinoline Modified Expanded Graphite Electrode for the Detection of Cuprous Ions in Electrolytic Copper Foil Electrolyte. [PDF]

Materials (Basel)
Ming Z, Wang W, Jiang D, Wang P, Sun Y, Wu Q, Chen Z.   +6 more
europepmc   +1 more source

Adaptive Regularization Using L-curve Method for Magnetic Inverse Source Problem

Transactions of the Society of Instrument and Control Engineers, 2006
Fumio KOJIMA, Daisuke YORIFUJI, Kazufumi ITO   +2 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Machine learning diagnostic framework for liver fibrosis in chronic hepatitis B based on routine laboratory tests. [PDF]

Medicine (Baltimore)
Hou L, Tang J, He W, Qin W.
europepmc   +1 more source