Results 181 to 190 of about 16,518,033 (301)

Programme journée d'étude du 15 juin 2012, « Femme et mode dans l’entre-deux-guerres: regards croisés franco-anglais » de 9h à 17h30, IHTP

open access: yes, 2012
Le 15 juin 2012, comme nous vous l'avions annoncé, le séminaire sur l'histoire de la mode de l'Institut du temps présent organise une journée d'étude franco-anglaise « Femme et mode dans l’entre-deux-guerres » de 9h à 17h30.
Sophie Kurkdjian
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

[Médailles antiques, moyen-âge temps modernes, etc...]

open access: yes, 1891
[Vente. Numismatique. 1891-06-15. Francfort][Collection. Numismatique. Schennis, Frédéric de. 1891][Collection. Numismatique. Köhler, L.. 1891][Collection. Numismatique. Lippert (dr).

core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Tailoring Plasmonic Waveguide-Coupled Cavities for CO<sub>2</sub> Sensing. [PDF]

open access: yesACS Omega
Khan GA   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

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