Results 91 to 100 of about 22,976 (239)

Evolution of the SARS‐CoV‐2 Main Protease Under Fitness Constraints Imposed by Folding Stability and Activity

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to evolve and diversify, leading to the emergence of immune‐evasive variants and underscoring the need for complementary antiviral strategies targeting conserved viral machinery. In this context, the main protease (Mpro) represents a potential therapeutic target because
David Ferreiro, Miguel Arenas
wiley   +1 more source

Simultaneous modification of Thermotoga maritima encapsulin subunits to produce multivalent nanoparticle vaccines for non‐typhoidal Salmonella enterica

The FEBS Journal, EarlyView.
This study investigates the modularity of encapsulin—a protein nanoparticle—by simultaneously inserting up to four distinct Salmonella epitopes within the encapsulin subunit. The encapsulin variants were transiently expressed in plants where they assembled into nanoparticles; however, their accumulation and stability varied depending on the ...
Carly A. Charron, Angelo Kaldis, Shabnam Shamriz, Moussa S. Diarra, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

Specific Interactions of the L10(L12)₄ Ribosomal Protein Complex with mRNA, rRNA, and L11

, 2016
Large ribosomal subunit proteins L10 and L12 form a pentameric protein complex, L10(L12)4, that is intimately involved in the ribosome elongation cycle.
David E. Draper (1919404), James R. Iben (840656)   +1 more
core   +1 more source

The worldwide burden of skin diseases: Lessons from the Global Burden of Disease data

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Skin diseases are a major public health concern worldwide, causing significant personal, economic and social burdens. The Global Burden of Disease (GBD) initiative provides valuable insights but underestimates the burden of skin diseases, emphasizing the urgent need for improved data collection and global collaboration among stakeholders.
Luigi Naldi, Simone Cazzaniga, Carsten Flohr, Marco May Lee, Claire Fuller, Roderick Hay, Esther E. Freeman, Rashmi Sarkar, Ricardo Romiti, Antonio Torrelo, Qianjin Lu, Ncoza Dlova, Visnja Zaborski Breton, Jennifer Austin, Matthias Augustin, Henry Lim, Luca Borradori   +16 more
wiley   +1 more source

Open Innovation for Circular Business Models: Addressing the Right Challenge at the Right Time

Journal of Product Innovation Management, EarlyView.
ABSTRACT Academic Summary In response to escalating societal challenges, such as climate change and resource constraints, this article examines the transition from linear toward circular business models (CBMs). It explores the challenges of CBM transitions and how to tackle them through open innovation.
Daniel Wörner, Lukas Falcke, Manuel Ritter, Shaun West, Thomas Friedli   +4 more
wiley   +1 more source

PRELIMINARY GENETIC CHARACTERIZATION OF RIBOSOMAL PROTEIN L10 IN SACCHAROMYCES CEREVISIAE [PDF]

, 2005
While recent research has focused on the exciting concept of the ribosome as a ribozyme, ribosomal proteins have been largely overlooked. This study focuses on four previously identified mutants of the ribosomal large subunit protein L10, in an effort to
Simmons, Mary Kecia Rigsby
core   +1 more source

Magnetization reversal process in FePt L10 nanoparticles [PDF]

, 2005
We have studied the magnetization reversals of FePt L10 particles. Lithographically fabricated single FePt particles and well isolated epitaxial FePt L10 nanoparticles have been investigated for a wide range of particle diameters D.
Kikuchi, Nobuaki, Kitakami, O., Shimada, Y., Okamoto, S.   +3 more
core   +1 more source

Archaeal Genes Code for GGDEF Domain Proteins With Diguanylate Cyclase Activity

Molecular Microbiology, EarlyView.
A biofilm‐like mode of growth is hypothesized to be required for the emergence of cellular life. Occurrence of common biofilm gene products in current Bacteria and Archaea is an indication for their previous presence in the last universal common ancestor LUCA and perhaps even in the first universal common ancestor FUCA.
Roman Sidorov, Li Li, Ali Dadvar, Irfan Ahmad, Stefan Spring, Jörg Overmann, Ute Römling   +6 more
wiley   +1 more source

Intramolecular Nickel‐Catalyzed Reductive Coupling: Enantioselective Synthesis of Tetrahydroisoquinolines and Related Heterocycles

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
The successful extension of the nickel‐catalyzed asymmetric coupling of polarized 1,3‐dienes with aldehydes to an intramolecular setting opens an efficient new entry into hydroxylated N‐heterocyclic compounds, most notably valuable tetrahydroisoquinolines.
Thilo Bender, Markus Leutzsch, Yannik Sell, Alois Fürstner   +3 more
wiley   +2 more sources

L10-FePt Media for Next-Generation Data Storage Devices [PDF]

, 2010
L10-ordered FePt thin films are a leading candidate for next-generation magnetic recording, such as bit-patterned media (BPM), heat-assisted magnetic recording (HAMR), and multilevel three-dimensional (ML3D) magnetic recording, because of their excellent
Fernandez, Robert Anthony
core