Feedback Regulation of c-Myc by Ribosomal Protein L11 [PDF]
Several ribosomal proteins including L11 have been shown to activate p53 by inhibiting oncoprotein MDM2, leading to inhibition of cell cycle progression. Our recent study showed that L11 also inhibits oncoprotein c-Myc. Overexpression of L11 inhibits c-Myc-induced transcription and cell proliferation, while reduction of endogenous L11 increases these c-
Mu-Shui, Dai, Rosalie, Sears, Hua, Lu
openaire +2 more sources
Subject and purpose of work: The study aims to analyse the existing marketing system along with marketing channels, costs, margins, and marketing efficiency.
Rani Sumista, Lal Choote, Kait Rohtas
doaj +1 more source
The impact of the COVID-19 pandemic on peer-to-peer accommodation businesses: The case of Airbnb
Aim/purpose – This study aims to examine the impact of the COVID-19 pandemic on peer-to-peer accommodation (P2PA), investigate the potential factors related to organizational resilience based on resilience resources and consumer threat response ...
Kiczmachowska Ewa E.
doaj +1 more source
Are R&D subsidies effective? The effect of industry competition
In this study, the author explores the effect of industry competition on public R&D subsidy effectiveness. He finds a non-linear threshold effect of industry competition on R&D subsidy effectiveness.
Xiang Xin
doaj +1 more source
Price Markups and Upstreamness in World Input-Output Data
This research uses the publicly available World Input-Output Database (WIOD) to investigate the relationship between an industry’s markup and its upstreamness, the industry’s position in the vertical chain of production; the research also identifies ...
Colonescu Constantin
doaj +1 more source
Recognition of ribosomal protein L11 by the protein trimethyltransferase PrmA [PDF]
Bacterial ribosomal protein L11 is post-translationally trimethylated at multiple residues by a single methyltransferase, PrmA. Here, we describe four structures of PrmA from the extreme thermophile Thermus thermophilus. Two apo-PrmA structures at 1.59 and 2.3 A resolution and a third with bound cofactor S-adenosyl-L-methionine at 1.75 A each exhibit ...
Hasan, Demirci +3 more
openaire +2 more sources
Discovery of Western European R1b1a2 Y chromosome variants in 1000 genomes project data: an online community approach. [PDF]
The authors have used an online community approach, and tools that were readily available via the Internet, to discover genealogically and therefore phylogenetically relevant Y-chromosome polymorphisms within core haplogroup R1b1a2-L11/S127 (rs9786076 ...
Richard A Rocca +6 more
doaj +1 more source
Objective: To evaluate and project the shelf life of GLPG4399, an early-phase clinical drug formulation by applying the Accelerated Stability Assessment Program (ASAP) approach.
Dattatray Modhave +2 more
doaj +1 more source
Heterosis in ridge gourd (Luffa acutangula L. Roxb.) for fruit yield and quality traits
The present investigation was conducted to investigate the extent of heterosis in 33 F1 hybrids of ridge gourd for growth, yield and quality traits in four environments comprising of two seasons and two locations during 2017.
Akshay Chittora +4 more
doaj +1 more source
Thermus thermophilus L11 Methyltransferase, PrmA, Is Dispensable for Growth and Preferentially Modifies Free Ribosomal Protein L11 Prior to Ribosome Assembly [PDF]
ABSTRACT The ribosomal protein L11 in bacteria is posttranslationally trimethylated at multiple amino acid positions by the L11 methyltransferase PrmA, the product of the prmA gene. The role of L11 methylation in ribosome function or assembly has yet to be determined, although the deletion of ...
Dale M, Cameron +5 more
openaire +2 more sources

