Results 91 to 100 of about 9,568,529 (304)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Artificial Intelligence Model Assists Knee Osteoarthritis Diagnosis via Determination of K-L Grade

Diagnostics
Background: Knee osteoarthritis (KOA) affects 37% of individuals aged ≥ 60 years in the national health survey, causing pain, discomfort, and reduced functional independence. Methods: This study aims to automate the assessment of KOA severity by training
Joo Chan Choi, Min Young Jeong, Young Jae Kim, Kwang Gi Kim   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Application Strategy for an Anthraquinone-Based Repellent and the Protection of Soybeans from Canada Goose Depredation

Human-Wildlife Interactions, 2019
Agricultural crops can sustain extensive damage caused by Canada geese (Branta canadensis) when these crops are planted near wetlands or brood-rearing sites.
Scott J. Werner, Matthew Gottlob, Charles D. Dieter, Joshua D. Stafford   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

ALEXANDRE RODRÍGUEZ GUERRA (ED.) LINGÜÍSTICA HISTÓRICA E DIALECTOLOXÍA: COORDENADAS DO CAMBIO LINGÜÍSTICO.

Diacrítica, 2019
Cf. L. E. García & X. L. Viñas (Eds.) (2014), Lingua, texto, diacronía. Estudos de lingüística histórica. Monografía 9 da Revista Galega de Filoloxía. A Coruña: Universidade da Coruña; Mariño Paz, Ramón, e Xavier Varela Barreiro (Eds).
Pedro Dono López
doaj   +1 more source

Multiaxial Kitagawa analysis of A356-T6

, 2011
Experimental Kitagawa analysis has been performed on A356-T6 containing natural and artificial defects. Results are obtained with a load ratio of R = -1 for three different loadings: tension, torsion and combined tension-torsion. The critical defect size
Atzori, Atzori, Atzori, Billaudeau, Brochu, Buffière, C. Nadot-Martin, Chan, Couper, D.M. Maijer, Dabayeh, De-Feng, Eshelby, Fan, Gadouini, Gall, Gao, Kumar, Lazzarin, Ludwig, M.J. Roy, McDowell, Mura, Murakami, Nadot, P.-G. Bardin, Papadopoulos, Susmel, Susmel, Taylor, Vu, Y. Nadot, Zhu   +32 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Improved Specific Energy Ni-h2 Cell [PDF]

Design optimization activities which have evolved and validated the necessary technology to produce Ni-H2 battery cells exhibiting a specific energy of 75-80 Whr/Kg (energy density approximately 73 Whr/L are summarized.
Miller, L.
core   +1 more source