Results 111 to 120 of about 9,568,529 (304)

Efektivitas Pupuk Hayati Cair dan Pemangkasan Daun terhadap Produksi Okra (Abelmoschus Esculentus L. Moench) [PDF]

, 2018
Penelitian ini bertujuan untuk mengetahui efektifitas penggunaan interaksi perlakuan konsentrasi pupuk hayati cair dengan umur pemangkasan daun terhadap produksi okra (Abelmoschus esculentus L. Moench). Dilaksanakan di Karangrejo, Sumbersari, Jember pada
Rahmawati, V. (Vita), Suroso, B. (Bejo), Wijaya, I. (Insan)   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Some aspects of a free jet phenomena to 105 L/D in a constant area duct [PDF]

Under certain conditions, inlets with a Borda type geometry were shown to exhibit sufficiently strong separation effects to permit the working fluid to flow through the duct as if it were a free jet.
Hendricks, R. C.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The use of biomarkers GP-73 and AFP in the early diagnosis of hepatocarcinoma associated with liver cirrhosis of HCV etiology

Журнал инфектологии
Purpose: comparative study of the informativeness of tumor markers GP-73 and AFP in the early diagnosis of hepatocellular carcinoma associated with liver cirrhosis of HCV etiology.Materials and methods: In the study, 71 people were divided into 4 groups.
A. K. Bayjanov, U. Yu. Ismоilov, A. S. Khikmatullaeva, Kh. P. Nasirova, J. A. Anvarov, Ch. B. Turaeva   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The complete chloroplast genome of Liparis brunnea Ormerod (Orchidaceae)

Mitochondrial DNA. Part B. Resources
Liparis brunnea Ormerod,a herbaceous species native to China, has a complete chloroplast genome of 150,145 bp (GC 36.90%), exhibiting a typical LSC (84,600 bp), SSC (15,701 bp) and IR (24,922 bp) structure.
Xin-jun Gan, Chu-qiao Tang, Pei-qi Yu, Huan-jin Chen, Jiu-xiang Huang   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source