ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
PENDIDlKAN POLITIK BAGI WANITA DA·LAM ERA REFORMASI 8AAT INI
In tile present era (Jjo rejorn1s ,11ere is considerable political tension and certain political education transforming current visi()n..\' oj'politics needs to be conducted as an effort to decrease tile political tenSi()1l.
Sri Pujiastuti Sri Pujiastuti
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Empowerment of elderly people trough physical exercise and service-learning methodology (S-L).
It is necessary a pedagogic view in the general and university education. A service focused to a social group should have a minimal quality, specially with elderly people.
Pedro Jesús Ruiz-Montero +1 more
doaj +1 more source
Prospecting the protein design landscape
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Sustaining the Higher Education Hub Model: The Challenge of Adequate Academic and Social Support Structures for International Students [PDF]
In recent years, the Education Hub (EH) concept has perhaps become the single most important focus of higher education policy in most Asian countries. A particular Asian Education Hub model (e.g.
Cameron Richards, Mohd Ismail Abd Aziz
doaj
Preserving flora diversity in the digitized herbarium collection [PDF]
The paper presents the results of digitations of the rare species of Tracheophyta in the herbarium collection of the Vyatka State University (Kirov, Russia).
Shabalkina Svetlana, Perestoronina Olga
doaj +1 more source

