Results 1 to 10 of about 417 (51)

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. [PDF]

open access: yesLupus Sci Med, 2017
Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms ...
Bernatsky S   +100 more
europepmc   +7 more sources

A genome-wide association study of marginal zone lymphoma shows association to the HLA region. [PDF]

open access: yesNat Commun, 2015
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−
Vijai J   +101 more
europepmc   +6 more sources

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases. [PDF]

open access: yesmBio, 2014
This project was supported by grants from the Wellcome Trust and the Medical Research Council UK (G.F.). J.S.C. and L.Y. are supported by the Wellcome Trust (079643/Z/06/Z)
Mousnier A   +9 more
europepmc   +5 more sources

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. [PDF]

open access: yesNat Commun, 2017
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel ...
Law PJ   +96 more
europepmc   +14 more sources

Genetically Determined Height and Risk of Non-hodgkin Lymphoma. [PDF]

open access: yesFront Oncol, 2019
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes.
Moore A   +78 more
europepmc   +8 more sources

Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes. [PDF]

open access: yesJ Transl Genet Genom, 2021
Aim: Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive ...
Moore A   +81 more
europepmc   +3 more sources

HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes. [PDF]

open access: yesCancer Res, 2018
A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA ...
Wang SS   +82 more
europepmc   +3 more sources

Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. [PDF]

open access: yesHum Mol Genet, 2016
Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL).
Machiela MJ   +119 more
europepmc   +3 more sources

Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses. [PDF]

open access: yesInt J Cancer
Obesity has been associated with non‐Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B‐cell lymphoma (DLBCL), follicular lymphoma ...
Moore A   +74 more
europepmc   +3 more sources

Spectral and Timing Properties of IGR J17091-3624 in the Rising Hard State During its 2016 Outburst [PDF]

open access: yes, 2017
We present a spectral and timing study of the NuSTAR and Swift observations of the black hole candidate IGR J17091-3624 in the hard state during its outburst in 2016.
Bachetti, Matteo   +10 more
core   +4 more sources

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