Results 241 to 250 of about 87,269 (310)

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Ultrasound‐Triggered Nanobubbles for Endothelial‐Targeted Drug Delivery in the Detection and Treatment of Doxorubicin‐Induced Cardiotoxicity

Advanced Healthcare Materials, EarlyView.
The DA/VTP‐NBs selectively recognized cardiac ECs damaged by DIC and achieved cell‐level targeted imaging. Then US‐triggered controlled release successfully enabled the release of DAPA within the DA/VTP‐NBs at the site of injury. This precise on‐demand drug release approach amplifies a series of localized therapeutic effects through the mtDNA‐mediated ...
Jun Zhang, Yi Ling, Xin Li, Deng Liu, Li Dong, Xuemei Chen, Yingxin Sun, Yongning Shang, Yanli Guo   +8 more
wiley   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

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Lab on Chip 3D Holographic Imaging

Imaging and Applied Optics 2014, 2014
3D imaging approaches based on holographic modality have been developed for Labon- Chip devices. Exploiting Digital Holography features a number of applications are illustrated thus demonstrating its great potentialities as coherent imaging tool for bio-microfluidic platform. © 2014 OSA.
Miccio L, Memmolo P, Merola F, Bianco V, Paturzo M, Fusco S, Netti PA, Ferraro P   +7 more
openaire   +4 more sources

Online-Analyse mit Lab-on-Chip-Systemen (Online Analysis with Lab-on-Chip Systems)

tm - Technisches Messen, 2004
Abstract Es werden Ergebnisse der Entwicklung und Erprobung unterschiedlicher Lab-on-Chip-Systeme auf der Basis von elektrochemischen Sensoren vorgestellt. Das Design und der technologisch anspruchsvolle Herstellungsprozess von Sensorchips, aber auch Möglichkeiten der Verkapselung werden beschrieben.
Sigrun Herrmann, Winfried Vonau
openaire   +1 more source

Femtosecond laser microstructuring for polymeric lab‐on‐chips

Journal of Biophotonics, 2012
AbstractThis paper provides an overview of femtosecond laser microfabrication in polymeric materials, with emphasis on lab‐on‐chip applications. Due to the nonlinear interaction of femtosecond laser pulses with polymers, laser‐induced modifications are localized to the focal volume, enabling high resolution patterning in 3D.
Shane M. Eaton, DE MARCO, CARMELA, MARTINEZ VAZQUEZ, REBECA, RAMPONI, ROBERTA, TURRI, STEFANO, CERULLO, GIULIO NICOLA, Roberto Osellame   +6 more
openaire   +3 more sources