Results 71 to 80 of about 67,874,633 (306)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems

, 2022
S.3963-3978Organ-on-chip (OoC) systems have become a promising tool for personalized medicine and drug development with advantages over conventional animal models and cell assays.
Rogal, Julia, Schneider, S., Weener, H.J., Bubeck, M., Meer, A.D. van der, Loskill, P., Weiss, M., Heymann, M., Rojas, C.   +8 more
core   +1 more source

Functionalized monodisperse microbubble production: microfluidic method for fast, controlled, and automated removal of excess coating material

Microsystems & Nanoengineering
Functionalized monodisperse microbubbles have the potential to boost the sensitivity and efficacy of molecular ultrasound imaging and targeted drug delivery using bubbles and ultrasound.
M. R. P. van den Broek, M. Versluis, A. van den Berg, T. Segers   +3 more
doaj   +1 more source

Cells in the 3D biomatrix on-chip: better mimicking the real micro-physiological system

Next Materials
Recent advances in microfluidic technology and biomaterial science have augmented the use of organ-on-chip (OoC) technology to closely mimic the human pathophysiology.
Michele D’Orazio, Joanna Filippi, Gianni Antonelli, Giorgia Curci, Paola Casti, Arianna Mencattini, Gianluca Cidonio, Eugenio Martinelli   +7 more
doaj   +1 more source

Online monitoring of biofouling using coaxial stub resonator technique

Sensing and Bio-Sensing Research, 2015
Here we demonstrate the proof-of-principle that a coaxial stub resonator can be used to detect early stages of biofilm formation. After promising field tests using a stub resonator with a stainless steel inner conductor as sensitive element, the ...
N.A. Hoog, M.J.J. Mayer, H. Miedema, W. Olthuis, A.A. Tomaszewska, A.H. Paulitsch-Fuchs, A. van den Berg   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Ruthenium Oxide pH Sensing for Organs-On-Chip Studies

Proceedings, 2018
A ruthenium oxide (RuOx) electrode is being developed as potentiometric pH sensor for organs-on-chip applications. Open-circuit potential (OCP) of the RuOx electrode showed a response of −58.05 mV/pH, with no cross-sensitivity to potentially ...
Esther Tanumihardja, Wouter Olthuis, Albert van den Berg   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reference-Electrode Free pH Sensing Using Impedance Spectroscopy

Proceedings, 2018
We present a reference-electrode free sensor able to measure both pH and conductivitybased on impedance spectroscopy. The electrode is made of a layer of indium-tin-oxide (ITO).
Laura Folkertsma, Lennart Gehrenkemper, Jan Eijkel, Karin Gerritsen, Mathieu Odijk   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source