Results 31 to 40 of about 501,707 (258)

Noumenal Labs White Paper: How To Build A Brain

CoRR
This white paper describes some of the design principles for artificial or machine intelligence that guide efforts at Noumenal Labs. These principles are drawn from both nature and from the means by which we come to represent and understand it. The end goal of research and development in this field should be to design machine intelligences that augment
Maxwell J. D. Ramstead, Candice Pattisapu, Jason G. Fox, Jeff Beck   +3 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Factors affecting selenium-enrichment efficiency, metabolic mechanisms and physiological functions of selenium-enriched lactic acid bacteria

Journal of Future Foods, 2022
Selenium (Se)-enriched lactic acid bacteria (LAB) are live bacteria preparations that accumulate and bio-transform inorganic Se into organic Se forms including Se-nanoparticles (SeNPs), Se-amino acids and selenoproteins. Se-enriched LAB can play the dual
Jiajun Liao, Chenghua Wang
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Capillary Flow-Based One-Minute Quantification of Amyloid Proteolysis

Biosensors
Quantifying the formation and decomposition of amyloid is a crucial issue in the development of new drugs and therapies for treating amyloidosis. The current technologies for grasping amyloid formation and decomposition include fluorescence analysis ...
Taeha Lee, Da Yeon Cheong, Kang Hyun Lee, Jae Hyun You, Jinsung Park, Gyudo Lee   +5 more
doaj   +1 more source

Effect of Sucrose and Lactic Acid Bacteria Additives on Fermentation Quality, Chemical Composition and Protein Fractions of Two Typical Woody Forage Silages

Agriculture, 2021
Paper mulberry (PM) and mulberry (MU) have been considered potential substitutes for traditional forages in response to the increasing demand for high-protein feed for livestock.
Xuekai Wang, Han Liu, Yixiao Xie, Yingchao Zhang, Yanli Lin, Yulong Zheng, Xueping Yang, Ningwei Wang, Kuikui Ni, Fuyu Yang   +9 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A Microfluidic Paper-Based Lateral Flow Device for Quantitative ELISA

Micro
This study presents an innovative lateral flow microfluidic paper-based analytical device (μPAD) designed for conducting quantitative paper-based enzyme-linked immunosorbent assays (p-ELISA), seamlessly executing conventional ELISA steps in a paper-based
Ashutosh Kumar, Cameron Hahn, Stephen Herchen, Alex Soucy, Ethan Carpio, Sophia Harper, Nassim Rahmani, Constantine Anagnostopoulos, Mohammad Faghri   +8 more
doaj   +1 more source

Instructing nontraditional physics labs: Toward responsiveness to student epistemic framing

Physical Review Physics Education Research, 2023
[This paper is part of the Focused Collection on Instructional labs: Improving traditions and new directions.] Research on nontraditional laboratory (lab) activities in physics shows that students often expect to verify predetermined results, as takes ...
Meagan Sundstrom, Rebeckah K. Fussell, Anna McLean Phillips, Mark Akubo, Scott E. Allen, David Hammer, Rachel E. Scherr, N. G. Holmes   +7 more
doaj   +1 more source