Results 141 to 150 of about 6,064,561 (323)

Singular-phase nanooptics: towards label-free single molecule detection

, 2013
Non-trivial topology of phase is crucial for many important physics phenomena such as, for example, the Aharonov-Bohm effect 1 and the Berry phase 2. Light phase allows one to create "twisted" photons 3, 4 , vortex knots 5, dislocations 6 which has led ...
Ansell, D., Britnell, L., Geim, A. K., Gorbachev, R. V., Grigorenko, A. N., Jalil, R., Kabashin, A. V., Kravets, V. G., Novoselov, K. S., Schedin, F., Thackray, B.   +10 more
core   +3 more sources

Label‐Free Identification of White Blood Cells Using Machine Learning

Cytometry Part A, 2019
White blood cell (WBC) differential counting is an established clinical routine to assess patient immune system status. Fluorescent markers and a flow cytometer are required for the current state‐of‐the‐art method for determining WBC differential counts.
Mariam Nassar, M. Doan, A. Filby, O. Wolkenhauer, D. Fogg, J. Piasecka, C. Thornton, Anne E Carpenter, H. Summers, P. Rees, H. Hennig   +10 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography

Nature Communications
The ability to image tissues in three dimensions (3D) with label-free molecular contrast at the mesoscale would be a valuable capability in biology and biomedicine.
Elzbieta Stepula, Anders R. Walther, Magnus Jensen, Dev R. Mehrotra, Mu H. Yuan, Simon V. Pedersen, Vishal Kumar, Eileen Gentleman, Michael B. Albro, Martin A. B. Hedegaard, Mads S. Bergholt   +10 more
doaj   +1 more source

Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo [PDF]

, 2020
Significance: Detection and characterization of circulating tumor cells (CTCs), a key determinant of metastasis, are critical for determining risk of disease progression, understanding metastatic pathways, and facilitating early clinical intervention.
Cornelius, Lynn A., Hai, Pengfei, Li, Yang, Qu, Yuan, Shmuylovich, Leonid, Wang, Lihong V., Zhu, Liren   +6 more
core   +1 more source

Nanopore electro-osmotic trap for the label-free study of single proteins and their conformations

bioRxiv, 2021
S. Schmid, Pierre Stömmer, Hendrik Dietz, C. Dekker   +3 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Route Towards a Label-free Optical Waveguide Sensing Platform Based on Lossy Mode Resonances [PDF]

, 2019
According to recent market studies of the North American company Allied Market Research, the field of photonic sensors is an emerging strategic field for the following years and it is expected to garner $18 billion by 2021.
Arregui, Francisco Javier, Ascorbe, Joaquin, Corres, Jesús María, De Acha, Nerea, Del Villar, Ignacio, Diaz, S., Elosúa, César, Goicoechea, Javier, Hernaez, Miguel, Imas, J. J., Lopez, D., Matias, Ignacio Raul, Ozcariz, A., Socorro, A.B., Urrutia, Aitor, Vitoria, I., Zamarreño, Carlos R., Zubiate, Pablo   +17 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing

Advanced Science
High sensitivity and high quality‐factor are crucial for achieving outstanding sensing performance in photonic biosensors. However, strong optical field confinement and high light–biomolecule interactions on photonic surfaces are usually contradictory ...
Yuqiao Zheng, Jiacheng Sun, Yaqing Ma, Hongyong Zhang, Zhen Cui, Giannis G. Paschos, Xixi Song, Ying Tao, Pavlos Savvidis, Wei Kong, Liaoyong Wen, Sumin Bian, Mohamad Sawan   +12 more
doaj   +1 more source