Results 21 to 30 of about 856,482 (219)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Deformation Behavior and Low-Carbon Assessment of Large-Span Beam with Fully Recycled Concrete [PDF]

中国工程科学
As global construction solid wastes surged and to achieve the carbon peak and carbon neutrality goals, the application of fully recycled coarse aggregate concrete (FRCAC, 100% replacement rate) in structural engineering has emerged as a breakthrough ...
Jianzhuang Xiao, Yupo Pan, Chunhui Wang, Haibo Fang, Ruming Liang, Xuyao Ge, Pujin Wang, Xiangshuo Guan, Haolin Xu, Jiaqian Ning, Yao He, Tao Ding, Xuwen Xiao   +12 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Strengthening the Industrial Foundation: Advancing the Industrial Foundation Re-engineering Project and Winning the Campaign for Industrial Foundation Upgrading [PDF]

中国工程科学
A strong industrial foundation is crucial for developing new-quality productive forces and strengthening the manufacturing sector in China. It also serves as an industrial cornerstone for establishing self-reliant industrial and supply chains ...
Yongxiang Lu, Ji Zhou, Xuedong Chen, Yong Gan, Zheng You, Gang Zhang, Xianming Qu, Yuan Xue, Minghao Zhu, Xiaoying Yang, Jiyuan Zang, Yishana Gu   +11 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Digital Intelligence Pathology Platform and Its Service Pattern [PDF]

中国工程科学
Pathological diagnosis is the cornerstone for clinical diagnosis and treatment decision-making. The digital intelligence pathology platform built by integrating artificial intelligence, big data, and other information technologies has great application ...
Xiaohong Chen, Liu Liu, Yajua Niu, Xiaoliang Liu, Xiaohai Li, Jianhua Zhou, Junpu Wang   +6 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Value Realization of Carbon Sink Ecological Products: Theoretical Foundation and Practice Paths [PDF]

中国工程科学
The value realization of carbon sink ecological products is a vital component of the broader ecological product value realization system. Its theoretical elaboration and practical exploration are of great significance to synergistically advance ...
Yanan Ren, Jiming Hao, Jinping Tian, Xing Li, Lyujun Chen   +4 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Ethical Risk Identification, Governance, and Foresight of Medical Foundation Models [PDF]

中国工程科学
The medical field is undergoing an intelligent transformation characterized by the emergence of multimodal foundation models. While technological empowerment brings unprecedented opportunities, it is accompanied by profound ethical risks.
Liu Liu, Xin Zhang, Qiqi Zhang, Jie Liu, Ziyu Liu, Huiling Wang, Hanxi Yi, Weiyuan Wang, Ousmane Diabate, Junpu Wang   +9 more
doaj   +1 more source