Results 21 to 30 of about 280,442 (249)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Optical label switching

Optical Fiber Communication Conference and International Conference on Quantum Information, 2001
Summary form only given. The design and implementation of a optical label switched router for packet switched WDM networks will be presented. The algorithms of generating optical labels, look-up tables, routing protocols, and a scaleable network architecture similar to IP/MPLS in optical domain will also be discussed.
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Relabelling Algorithms for Large Dataset Mixture Models [PDF]

, 2014
Mixture models are flexible tools in density estimation and classification problems. Bayesian estimation of such models typically relies on sampling from the posterior distribution using Markov chain Monte Carlo.
Fan, Yanan, Zhu, Wanchuang
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Performance Evaluation of the Labelled OBS Architecture [PDF]

, 2010
A comparison of three different Optical Burst Switching (OBS) architectures is made, in terms of performance criteria, control and hardware complexity, fairness, resource utilization, and burst loss probability. Regarding burst losses, we distinguish the
Brochier, Nicolas, Cousin, Bernard, Legrand, Thomas   +2 more
core   +5 more sources

Emulation of GMPLS-controlled Ethernet Label Switching [PDF]

2009 5th International Conference on Testbeds and Research Infrastructures for the Development of Networks & Communities and Workshops, 2009
Last decades bridged Ethernet has been the de facto standard layer 2 technology for LAN environments. This is mainly because it is easy to deploy, it has low cost and is relatively robust. These attractive properties together with highly increasing PHY speeds result in several initiatives of research projects and standardization bodies to extend ...
Tavernier, Wouter, Papadimitriou, D., Colle, Didier, Pickavet, Mario, Demeester, Piet   +4 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

DiffServ Traffic Management with MPLS [PDF]

, 2004
La tesi consta di una prima parte teorica, dove vengono analizzate nell’ordine: i) Differentiated Services; ii) MultiPotocol Label Switching; iii) Traffic Engineering.
Lepera, Pasquale
core