Results 171 to 180 of about 25,867,085 (318)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

An Effective Land Type Labeling Approach for Independently Exploiting High-Resolution Soil Moisture Products Based on CYGNSS Data [PDF]

, 2022
Yan Jia, Shuanggen Jin, Qingyun Yan, Patrizia Savi, Rongchun Zhang, Wenmei Li   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Label-aware distance mitigates temporal and spatial variability for clustering and visualization of single-cell gene expression data [PDF]

Shaoheng Liang, Jinzhuang Dou, Ramiz Iqbal, Ken Chen   +3 more
openalex   +1 more source

Raw Data for 'A Systematic Classification and Labelling Approach to Support a Circular Economy Ecosystem for NdFeB-Type Magnet'

, 2023
Carlo Burkhardt, Benjamin Podmiljšak, Antje Lehmann, Spomenka Kobe   +3 more
openalex   +1 more source

DeepIFC : Virtual fluorescent labeling of blood cells in imaging flow cytometry data with deep learning [PDF]

, 2023
Veera A. Timonen, Erja Kerkelä, Ulla Impola, Leena Penna, Jukka Partanen, Outi Kilpivaara, Mikko Arvas, Esa Pitkänen   +7 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Grounded Semantic Role Labelling from Synthetic Multimodal Data for Situated Robot Commands [PDF]

Claudiu Daniel Hromei, Antonio Scaiella, Danilo Croce, Roberto Basili   +3 more
openalex   +1 more source

Pattern Labelling of Business Communication Data [PDF]

, 2022
Muhammed-Fatih Kaya
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source