Results 201 to 210 of about 25,867,085 (318)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Bridging the Pathology Domain Gap: Efficiently Adapting CLIP for Pathology Image Analysis with Limited Labeled Data. [PDF]

Comput Vis ECCV
Lai Z, Chauhan J, Dugger BN, Chuah CN.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Craniomaxillofacial landmarks detection in CT scans with limited labeled data via semi-supervised learning. [PDF]

Heliyon
Tao L, Zhang X, Yang Y, Cheng M, Zhang R, Qian H, Wen Y, Yu H.   +7 more
europepmc   +1 more source

Off-label use of targeted therapies in osteosarcomas: data from the French registry OUTC’S (Observatoire de l’Utilisation des Thérapies Ciblées dans les Sarcomes) [PDF]

, 2015
Mathilde Penel‐Page, Isabelle Ray‐Coquard, Julie Larcade, Magali Girodet, L. Bouclier, Muriel Rogasik, Nadège Corradini, Natacha Entz‐Werlé, Laurence Brugières, Julien Dômont, Cyril Lervat, Sophie Piperno‐Neumann, Hélène Pacquement, Jacques‐Olivier Bay, Jean‐Claude Gentet, A. Thyss, L. Chaigneau, B. Narciso, H. Cornille, Jean‐Yves Blay, Perrine Marec‐Bérard   +20 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Identifying retinopathy in optical coherence tomography images with less labeled data via contrastive graph regularization. [PDF]

Biomed Opt Express
Hu S, Tang H, Luo Y.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Artificial intelligence tools trained on human-labeled data reflect human biases: a case study in a large clinical consecutive knee osteoarthritis cohort. [PDF]

Sci Rep
Lenskjold A, Brejnebøl MW, Rose MH, Gudbergsen H, Chaudhari A, Troelsen A, Moller A, Nybing JU, Boesen M.   +8 more
europepmc   +1 more source

SELP: Semi-supervised evidential label propagation algorithm for graph data clustering

, 2017
Kuang Zhou, Arnaud Martin, Quan Pan, Zhunga Liu   +3 more
openalex   +2 more sources