Results 181 to 190 of about 1,863,396 (330)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Tunable dual-AAV sparse labeling of PV⁺ retinal ganglion cells enables single-neuron projection by fMOST. [PDF]

Front Neural Circuits
Zhou L, Tan G, Li Y, Yuan M, Jin S, Zhang W, Wang Q, Shen Y.   +7 more
europepmc   +1 more source

SPRECware: Software Tools for Standard PREanalytical Code (SPREC) Labeling – Effective Exchange and Search of Stored Biospecimens [PDF]

, 2012
Umberto Nanni, Fay Betsou, Silvia Riondino, Luisa Rossetti, Antonella Spila, Maria Giovanna Valente, David Della‐Morte, Raffaele Palmirotta, Mario Roselli, Patrizia Ferroni, Fiorella Guadagni   +10 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Establishment of Dimethyl Labeling-based Quantitative Acetylproteomics in Arabidopsis

, 2018
Shichang Liu, Fengchao Yu, Zhu Yang, Tingliang Wang, Hairong Xiong, Caren Chang, Weichuan Yu, Ning Li   +7 more
openalex   +1 more source

Learning More from Mixed Emotions: A Label Refinement Method for Emotion Recognition in Conversations

, 2023
Jintao Wen, Geng Tu, Rui Li, Dazhi Jiang, Wenhua Zhu   +4 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Metabolic rewiring and biomass redistribution enable optimized mixotrophic growth in Chlamydomonas. [PDF]

Proc Natl Acad Sci U S A
Koley S, Foley K, Perrine Z, Morley SA, Kambhampati S, Gomez O, Chu KL, Chou YH, Wei M, Tzeng SC, Williams R, Umen JG, Allen DK.   +12 more
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Site-Selective Protein Modification via Peptide-Directed Proximity Catalysis. [PDF]

ACS Omega
Raynal L, Nabarro J, Miller LM, Dowle AA, Moul SL, Masithi P, Johnson SD, Fascione MA, Spicer CD.   +8 more
europepmc   +1 more source