Results 211 to 220 of about 1,863,396 (330)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation. [PDF]

Elife
Arnould B, Martz A, Belzanne P, Peralta FA, Cevoli F, Hovhannisyan V, Goumon Y, Hosy E, Specht A, Grutter T.   +9 more
europepmc   +1 more source

Cerebral blood flow characteristics following hemodialysis initiation in older adults: A prospective longitudinal pilot study using arterial spin labeling imaging

, 2020
Xiufeng Li, Yelena Slinin, Lin Zhang, Donald R. Dengel, David E. Tupper, Gregory J. Metzger, Anne M. Murray   +6 more
openalex   +1 more source

Subcellular Distribution of a Fluorescence-Labeled Combi-Molecule Designed to Block Epidermal Growth Factor Receptor Tyrosine Kinase and Damage DNA with a Green Fluorescent Species [PDF]

, 2010
Margarita Todorova, Anne‐Laure Larroque, Sabine Dauphin-Pierre, Youqiang Fang, Bertrand J. Jean‐Claude   +4 more
openalex   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Lgr5+ ductal cells of von Ebner's glands: Candidate stem cells for turnover of posterior tongue taste buds. [PDF]

PLoS One
Harrison TA, Downs AM, Slepian AJ, van Es JH, Clevers H, Defoe DM.   +5 more
europepmc   +1 more source

A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870 [PDF]

, 2013
Alexander Edgar, Matthias Trost, Colin Watts, Rossana Zaru   +3 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Homoeopathic management in depressive episodes: A prospective, unicentric, non-comparative, open-label observational study

, 2013
Praveen Oberai, Indira Balachandran, KR Janardhanan Nair, Anita Sharma, Vijay Pratap Singh, Vikram Singh, Chaturbhuja Nayak   +6 more
openalex   +1 more source