Results 81 to 90 of about 290,195 (301)

„Mut des Wortes“ – „Mut der Tat“?

Österreichische Zeitschrift für Geschichtswissenschaften, 2010
The cultural landscape of the capital of the first Czechoslovak Republic was marked by many different spaces of communication which were closely linked to certain communities (formed on the basis of national / ‘ethnic’ association).
Stefan Benedik
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Significant shortcomings in vape product labelling

, 2023
The current lack of adequate labelling on vape liquids, also known as e-liquid or e-juice, has contributed to an increase in acute nicotine poisoning among children. An ongoing study by Look Keyun, Dr Ser Hooi Leng, Dr Amar Daud Iskandar Abdullah, and
Look, Keyun, Ser, Hooi Leng *, Long, Chiau Ming *, Amar, Daud Iskandar Abdullah *   +3 more
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

[2H26]-1-epi-Cubenol, a completely deuterated natural product from Streptomyces griseus

Beilstein Journal of Organic Chemistry, 2013
During growth on fully deuterated medium the volatile terpene [2H26]-1-epi-cubenol was released by the actinomycete Streptomyces griseus. This compound represents the first completely deuterated terpene obtained by fermentation.
Christian A. Citron, Jeroen S. Dickschat
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

TOP2LABEL: EXPLAINABLE ZERO SHOT TOPIC LABELLING USING KNOWLEDGE GRAPHS

, 2022
We presented the first zero-shot model to generate all three types of textual labels (i.e., 1. One Word Label, 2. Sentence Label, and 3. Summary Label) for automatically generated topics. We have defined our evaluation matrix based on BERTScore, which is
Chaudhary, Akhil
core  

Beyond labelling: What strategies do nut allergic individuals employ to make food choices? A qualitative study [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. Copyright @ 2013 Barnett et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use ...
Raats Monique M., Barnett, J., Konstantina Vasileiou, Lucas, Jane S., Konstantina Vasileiou (277699), Vasileiou, Konstantina, Raats, MM, Raats, Monique M., Raats, M.M., Jane S. Lucas (277702), Gowland, M. Hazel, M. Hazel Gowland (277700), Julie Barnett (277698), Monique M Raats, Julie Barnett, Gowland M. Hazel, Barnett, J, M Hazel Gowland, Barnett, Julie, Gowland, MH, Vasileiou, K, Jane S Lucas, Lucas Jane S., Gowland, M.H., Barnett Julie, Lucas, J.S., Lucas, JS, Monique M. Raats (277701), Vasileiou Konstantina   +28 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source