Results 61 to 70 of about 14,435 (208)

Comparing the Molecular Pharmacological Properties of Existing β‐Blockers to Determine the Theoretically Most “Ideal” Anti‐Cancer β‐Blocker

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT There is increasing evidence, from cellular, animal and human epidemiological studies, linking β‐blockers with reductions in cancer growth and metastasis. Propranolol is the most investigated β‐blocker for cancer; although as many different off‐patent β‐blockers exist, there is little commercial incentive to drive comparative clinical trials ...
Jillian G. Baker
wiley   +1 more source

Comparison of Oral Preoperative Clonidine with Infusion of Intraoperative Labetalol on Bleeding during Tympanoplasty Surgery [PDF]

Iranian Journal of Otorhinolaryngology
Introduction: Surgical bleeding is one of the most critical complications in various surgical procedures. In middle ear surgery, managing bleeding is a significant challenge for anesthesiologists because even minor bleeding can obstruct the surgeon's ...
Mohamad Reza Afzalzadeh, Mostafa Mahdavi, Saleheh Asghari, Maryam Emadzadeh   +3 more
doaj   +1 more source

Cardiac dysfunction during adverse maternal outcomes in hypertensive disorders of pregnancy

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 2, Page 280-287, February 2026.
In pregnancies complicated by hypertensive disorders, peripartum adverse maternal outcomes are associated with diastolic cardiac dysfunction. Elevated E/e' ratio and left atrial volume index highlight the need for targeted cardiovascular monitoring and long‐term follow‐up.
Veronica Giorgione, Jamie Kitt, Paul Leeson, Asma Khalil, Jamie O'Driscoll, Basky Thilaganathan   +5 more
wiley   +1 more source

Lipid Emulsion Mitigates the Cardiotoxic Effects of Labetalol in Rat Cardiomyoblasts

Cells
Lipid emulsion has recently emerged as an effective agent for improving the cardiotoxicity of highly lipophilic drugs. However, its effect on cardiotoxicity induced by labetalol, a nonselective beta-blocker, remains unknown.
Gyujin Sim, Seong-Ho Ok, Soo Hee Lee, Kyeong-Eon Park, Seunghyeon Park, Ju-Tae Sohn   +5 more
doaj   +1 more source

A Retrospective Study on the Impact of Primary Aldosteronism in Pregnancy (H.A.P.P.I. Study Group)

Clinical Endocrinology, Volume 104, Issue 2, Page 113-122, February 2026.
ABSTRACT Objective Primary aldosteronism (PA) is a common cause of hypertension in young women. However, there is a paucity of data regarding its impact during pregnancy. The primary objective of this study was to describe the occurrence of hypertensive disorders of pregnancy (HDP) in PA.
Diana Oprea, Frédérique Lefrançois, Matthieu St‐Jean, Anne‐Marie Côté, Marie‐Ève Roy‐Lacroix, Mandy Malick, Pierre‐Luc Mallet, Nadine Sauvé   +7 more
wiley   +1 more source

Comparison of the Effects of Dexmedetomidine and Labetalol on Controlled Hypotension in Maxillofacial Surgery

Journal of Ardabil University of Medical Sciences, 2020
Background & objectives: The use of controlled hypotension is important to reduce bleeding in some surgeries. This study aimed to determine the effects of dexmedetomidine (DEX) and labetalol for induced hypotension in maxillofacial fractures surgery ...
Ali Alizadeh, Hamid Kayalha, Zohreh Yazdi, Aidin Binazadeh, SHahram Rastak, Mohammad Sofiabadi   +5 more
doaj  

Concurrent Reversible Cerebral Vasoconstriction Syndrome and Bilateral Vertebral Artery Dissection in the Postpartum Period: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Reports of postpartum women with concurrent reversible cerebral vasoconstriction syndrome (RCVS) and bilateral vertebral artery dissection (VAD) are rare. Guidelines on the management of future pregnancies in these patients are also limited.
Rong Jin, Huiliang Melissa Tang, Shavi Fernando   +2 more
wiley   +1 more source

In Vitro Assessment of Clevidipine Using the Profilin1 Hypertensive Mouse Model

Pharmaceuticals, 2013
Hypertension represents a major risk factor for cardiovascular events, associating with vascular hypertrophy and dysfunction in resistance vessels. Clevidipine is a novel antihypertensive drug working as a selective calcium channel antagonist with an ...
Hamdy H. Hassanain, Mohamed D. H. Hassona, Erika G. Puente, Chengwen Sun, Zeinb A. Abouelnaga, David B. Tulman, Sergio D. Bergese   +6 more
doaj   +1 more source

Toxicodermias por beta-bloqueantes [PDF]

, 2019
La hipertensión arterial es una enfermedad crónica que disminuye la calidad y expectativa de vida, ya que se agrava la morbimortalidad cardiovascular y renal.
Pradillo Heras, Cristina
core  

A Novel Tertiary Carbamate Prodrug Strategy to Overcome Metabolic Barriers in Oral Ketamine Delivery

ChemMedChem, Volume 21, Issue 2, January 2026.
This study describes the development of an orally optimized ketamine prodrug designed to improve pharmacokinetic properties, extend therapeutic efficacy, and minimize adverse effects and abuse liability. Ketamine, a rapid‐acting N‐methyl‐D‐aspartate (NMDA) receptor antagonist, has therapeutic potential beyond anesthesia, including treatment‐resistant ...
Juulia Järvinen, Santosh Kumar Adla, Janne Tampio, Aaro Jalkanen, Kenneth B. Sloan, Kristiina M. Huttunen, Jarkko Rautio   +6 more
wiley   +1 more source