Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu +6 more
wiley +1 more source
Lead fractionation and availability in contaminated soils: a comparative study of organic wastes and zeolite as stabilizing agents. [PDF]
de Resende PS +3 more
europepmc +1 more source
Abstract BACKGROUND Recombinant protein expression in Escherichia coli frequently results in the formation of inclusion bodies (IBs), which provide high protein accumulation but often require additional steps to recover functional protein. Although culture conditions strongly influence IB physicochemical and structural characteristics, the impact of ...
Ximena Gómez‐Gil +7 more
wiley +1 more source
The Fragile Sink: Reconceptualizing Soil Carbon Stabilization and Its Vulnerability Under Global Change. [PDF]
Iqbal MM +4 more
europepmc +1 more source
ABSTRACT Biochar and hydrochar have emerged as promising carbon‐based amendments for enhancing soil carbon sequestration and mitigating greenhouse gas emissions. This review synthesizes and critically compares current knowledge on the production technologies, physicochemical properties, stabilization mechanisms, carbon persistence, and life‐cycle ...
João Marcos Rodrigues dos Santos
wiley +1 more source
Food Security Versus Environmental Health: The Nitrogen Dilemma
ABSTRACT Nitrogen is an essential element for plant growth and, consequently, crop production. However, the cycling of nitrogen in the environment can have negative effects. Here, we review the historical development of scientific and public awareness of these effects and the influence this has had on political action to control them.
Henrike Mielenz +8 more
wiley +1 more source
Vegetation-Mediated Soil Organic Carbon Differentiation and Carbon Sequestration Strategies in a Typical Wetland of the North China Plain. [PDF]
Shi Z +10 more
europepmc +1 more source
Organic Matter Quality and Microbial Activity in Soils Managed With Brachiaria Succession
ABSTRACT Background Although succession systems and brachiaria improve soil quality, gaps remain in microbial community dynamics, activity, and soil organic matter stocks. Methods The objective was to evaluate the carbon (C) and nitrogen (N) stocks of soil organic matter fractions and their distribution, molecular characterization, enzyme activity ...
Siro Paulo Moreira +5 more
wiley +1 more source
Microbial Influence on Carbon Storage and Trace Element Speciation in Restored and Natural Mangrove Sediments: A Synthesis of the Current Understanding. [PDF]
Uddin MM +6 more
europepmc +1 more source
Perspectives of High‐Resolution Mass Spectrometry in Soil Science
ABSTRACT Soil biogeochemical research requires specific, sensitive, and accurate methods to identify and quantify organic molecules in order to trace biochemical processes and assess element cycling in complex, heterogenous systems. High‐resolution mass spectrometry (HRMS) has evolved into a transformative tool for unraveling the complex chemical ...
Bruno Glaser +11 more
wiley +1 more source

