Results 221 to 230 of about 3,483,745 (281)

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

open access: yesInterdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu   +6 more
wiley   +1 more source

Production of recombinant human granulocyte‐macrophage colony‐stimulating factor in thermoinducible E. coli: Tuning inclusion body architecture and protein yield via dissolved oxygen control

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Recombinant protein expression in Escherichia coli frequently results in the formation of inclusion bodies (IBs), which provide high protein accumulation but often require additional steps to recover functional protein. Although culture conditions strongly influence IB physicochemical and structural characteristics, the impact of ...
Ximena Gómez‐Gil   +7 more
wiley   +1 more source

Biochar and Hydrochar as Soil‐Based Carbon Sequestration Technologies: Implications for Greenhouse Gas Mitigation

open access: yesJournal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Biochar and hydrochar have emerged as promising carbon‐based amendments for enhancing soil carbon sequestration and mitigating greenhouse gas emissions. This review synthesizes and critically compares current knowledge on the production technologies, physicochemical properties, stabilization mechanisms, carbon persistence, and life‐cycle ...
João Marcos Rodrigues dos Santos
wiley   +1 more source

Food Security Versus Environmental Health: The Nitrogen Dilemma

open access: yesJournal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Nitrogen is an essential element for plant growth and, consequently, crop production. However, the cycling of nitrogen in the environment can have negative effects. Here, we review the historical development of scientific and public awareness of these effects and the influence this has had on political action to control them.
Henrike Mielenz   +8 more
wiley   +1 more source

Organic Matter Quality and Microbial Activity in Soils Managed With Brachiaria Succession

open access: yesJournal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Background Although succession systems and brachiaria improve soil quality, gaps remain in microbial community dynamics, activity, and soil organic matter stocks. Methods The objective was to evaluate the carbon (C) and nitrogen (N) stocks of soil organic matter fractions and their distribution, molecular characterization, enzyme activity ...
Siro Paulo Moreira   +5 more
wiley   +1 more source

Perspectives of High‐Resolution Mass Spectrometry in Soil Science

open access: yesJournal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Soil biogeochemical research requires specific, sensitive, and accurate methods to identify and quantify organic molecules in order to trace biochemical processes and assess element cycling in complex, heterogenous systems. High‐resolution mass spectrometry (HRMS) has evolved into a transformative tool for unraveling the complex chemical ...
Bruno Glaser   +11 more
wiley   +1 more source

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