Results 211 to 220 of about 1,084,008 (276)

Comparison of Metformin PBPK Models Incorporating Placental Transfer to Predict Fetal and Maternal Exposure

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling of placental drug transfer is an evolving tool for predicting fetal drug exposure. In this study, a pregnancy‐specific metformin PBPK model was developed, and the following four approaches were evaluated to predict metformin placental transfer: (1) perfusion‐limited model, and permeability ...
Jacqueline B. Tiley   +5 more
wiley   +1 more source

Oral misoprostol (PGE1) vs vaginal dinoprostone (PGE2) for labor induction: individual participant data meta‐analysis of randomized controlled trials

open access: yesUltrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective To compare the effectiveness and safety of oral misoprostol vs vaginal dinoprostone for the induction of labor (IOL) using an individual participant data (IPD) meta‐analysis. Methods We used a Cochrane review and searched Ovid MEDLINE, Ovid Embase, Ovid Emcare, CINAHL Plus, Scopus and ClinicalTrials.gov to identify randomized ...
S. Y. Tan   +13 more
wiley   +1 more source

Fetal cardiac remodeling in second trimester in pregnancies with pre‐eclampsia and/or fetal growth restriction: deep‐learning‐based approach using population‐wide data

open access: yesUltrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective Pre‐eclampsia (PE) and fetal growth restriction (FGR) have been shown to impact fetal cardiac remodeling in the third trimester and postnatally, with evidence to suggest that this leads to increased long‐term cardiovascular risk. This study aimed to examine fetal cardiac remodeling in pregnancies with PE and/or FGR during the second ...
C. A. Taksøe‐Vester   +9 more
wiley   +1 more source

Outcome of fetal ovarian cysts following in‐utero aspiration vs expectant management: multicenter cohort study

open access: yesUltrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective The primary aim was to evaluate pre‐ and postnatal morphological changes in large simple fetal ovarian cysts following in‐utero aspiration compared with expectant management. Secondary aims were to assess postnatal outcome in terms of surgical intervention and to evaluate complications associated with in‐utero aspiration.
V. Peyronnet   +10 more
wiley   +1 more source

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