Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity
Advanced Science, EarlyView.This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao +10 more
wiley +1 more source
Predictors of labour pain among primigravida mothers: A prospective observational study. [PDF]
J Educ Health PromotNandan L, Gohil J.
europepmc +1 more source
Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
Advanced Science, EarlyView.MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
Construction and Validation of a Prediction Model for Conversion to Cesarean Section in Primiparous Women Receiving Epidural Labor Analgesia: A Retrospective Cohort Study. [PDF]
Int J Womens HealthHuang X, Hua J.
europepmc +1 more source
Advanced Science, EarlyView.MarginPath is a novel vision‐language system that automates breast cancer margin assessment using a single label‐free multiphoton microscopy image. By integrating tumor‐associated collagen signatures with virtual H&E imaging, it generates accurate margin heatmaps and comprehensive diagnostic reports.
Shu Wang +15 more
wiley +1 more source
Perpetual connectivity as digital labor: a conceptual reframing of the always-on work culture. [PDF]
Front Public HealthMdhluli NI.
europepmc +1 more source
A Supramolecular Reversible and Anisotropic Conductive Adhesive for Flexible Electronics
Advanced Science, EarlyView.Supramolecular network‐based nanocomposites are developed as a stretchable conductive adhesive for flexible electronics. It's as convenient as traditional solders and constructs anisotropic conductive and robust stretchable connections among diverse soft/rigid materials.
Tongtong Li +8 more
wiley +1 more source
Parenting Stress and Couple Relationship Quality Among Transgender and Nonbinary Parents: The Roles of Discrepancy in Division of Childcare Labor and Gender Identity. [PDF]
Fam ProcessFang S, Tornello SL, Spadaro E.
europepmc +1 more source
Advanced Science, EarlyView.We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du +11 more
wiley +1 more source