Results 51 to 60 of about 1,746,025 (303)

Model-based small area estimation with no samples within the areas, by benchmarking to marginal cross-sectional and time-series estimates

Statistical Theory and Related Fields, 2020
Official monthly U.S. labour force estimation at the sub-State level (mostly counties) is based on what is known as the ‘Handbook’ (HB) method, one of the earliest uses of administrative data for small area estimation.
Danny Pfeffermann, Michael Sverchkov, Richard Tiller, Lizhi Liu   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Integrating evolutionary algorithms and enhanced-YOLOv8 + for comprehensive apple ripeness prediction

Scientific Reports
The assessment of apple quality is pivotal in agricultural production management, and apple ripeness is a key determinant of apple quality. This paper proposes an approach for assessing apple ripeness from both structured and unstructured observation ...
Yuchi Li, Zhigao Wang, Aiwei Yang, Xiaoqi Yu   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Severe Inhibition of Long-Chain Acyl-CoA Enoylhydratase (EC 4.2.1.74) in a Newborn Foal Suffering From Atypical Myopathy

Frontiers in Veterinary Science, 2021
In horses, congenital defects of energy production from long-chain fatty acids have not been described so far. In contrast, inhibition of fatty acid degradation caused by the toxins hypoglycin A and methylenecyclopropylglycine from various maple species ...
Johannes Sander, Johannes Sander, Michael Terhardt, Nils Janzen, Nils Janzen   +4 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Euler simulation of hydrocyclone pre-separation before oily wastewater membrane treatment based on Population balance model

Scientific Reports
Membrane technology is considered an effective technique for separating and purifying oily wastewater, and membrane fouling caused by surfactant adsorption or oil droplet blockage of pore channels.
Zhao Shuai, Xie Liqiu, Ding Laiyuan, Liu Yan, Sun Daming, Ren Yong   +5 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Microstructural characteristics of low-temperature (1400°C) sintered MgO obtained from seawater [PDF]

Science of Sintering, 2017
The purpose of this study was to investigate the influence of a rinsing of Mg(OH)2 precipitated from seawater by substoichiometric precipitation (80% precipitation) and the addition of TiO2 on microstructural characteristics of the MgO obtained ...
Jakić Jelena, Štefanić Goran, Labor Miroslav, Martinac Vanja   +3 more
doaj   +1 more source