Results 291 to 300 of about 1,388,320 (356)

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

open access: yesAdvanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun   +14 more
wiley   +1 more source

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

open access: yesAdvanced Science, EarlyView.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin   +11 more
wiley   +1 more source

Industrial Alkaline Electrolyzers Enabled by Interface‐Engineered Cobalt Oxide Electrodes for High‐Efficiency Water Splitting

open access: yesAdvanced Science, EarlyView.
Alkaline electrolysis is an important means to generate green hydrogen from water splitting, and its technical advance hinges critically on the breakthrough of catalytic electrodes capable of high current densities at low overpotentials. Here cobalt oxide electrodes engineered with metal cobalt transition layers are developed to assemble an industrial ...
Cheng Li   +7 more
wiley   +1 more source

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