Results 251 to 260 of about 12,830,568 (408)

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

French Labor Relations: A Functional Analysis

The Yale Law Journal, 1973
openaire   +2 more sources

Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function.

Molecular Endocrinology, 2006
J. Condon, D. Hardy, Kelly Kovaric, C. Mendelson   +3 more
semanticscholar   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Tongue microstructure physically constrains division of labor in bumblebee foraging. [PDF]

Proc Natl Acad Sci U S A
Huang Z, Wu S, Wu Q, Mai T, Zhao J, Wang B, Wu J.   +6 more
europepmc   +1 more source

Panel data estimates of the production function and product and labor market imperfections

, 2011
Sabien Dobbelaere, Jacques Mairesse
openalex   +2 more sources

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Pregnancy-related maternal and fetal outcomes following renal transplantation: a decade of experience at a tertiary care center in Saudi Arabia. [PDF]

BMC Pregnancy Childbirth
Hejazi J, Aljumaa A, Elmokattaf R, Aljumaa J, Al-Amoudi WA, Al-Amoudi SA, Aljumaa R, Desai S, Al Hennawi MM, Almugbel M.   +9 more
europepmc   +1 more source

Cognitive function of pregnant women: the problem of postoperative cognitive dysfunction in women after labor

, 2020
Aleksey V. Shchegolev, Д М Широков, Oksana A. Chernykh, I. V. Vartanova, Maria V. Khrabrova   +4 more
openalex   +2 more sources

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source